Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DESM_HUMAN
Description:desmin [Source:HGNC Symbol;Acc:2770]
Location:chr2 q35
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S12SSQRVsSYRRTAurB(Aurora BRegPhos
S358EDRFAsEASGYFilament; Myosin_tail_1; PhosphoSitePlus
T450TVMIKtIETRDGASPhosphoSitePlus
Y54VTSRVyQVSRTFilament_headPhosphoSitePlus
S12SSQRVsSYRRTFilament_headPhosphoSitePlus
T17SSYRRtFGGAPROCK1HPRD; RegPhos
Y388RHLREyQDLLNFilament; Myosin_tail_1; PhosphoSitePlus
T77SRLGTtRTPSSROCK_groupphosphoELM; RegPhos
S60QVSRTsGGAGGAurBRegPhos
T332QIQSYtCEIDAFilament; Myosin_tail_1; PhosphoSitePlus
S28GFPLGsPLSSPHPRD
S31LGSPLsSPVFPFilament_headPhosphoSitePlus
S32GSPLSsPVFPRHPRD
T77SRLGTtRTPSSFilament_head; IncA; DUF8PhosphoSitePlus
S414LEGEEsRINLPFilament; GAS; Spc7; IncAPhosphoSitePlus
T17SSYRRtFGGAPAurB(Aurora BRegPhos
S28GFPLGsPLSSPFilament_headPhosphoSitePlus
Y83RTPSSyGAGELFilament_head; IncA; DUF8PhosphoSitePlus
S57RVYQVsRTSGGFilament_headPhosphoSitePlus
S32GSPLSsPVFPRFilament_headPhosphoSitePlus
Y281DIRAQyETIAAFilament; Myosin_tail_1; PhosphoSitePlus
S13SQRVSsYRRTFFilament_headPhosphoSitePlus
T17SSYRRtFGGAPFilament_headPhosphoSitePlus
T76ASRLGtTRTPSROCK_groupphosphoELM; RegPhos
Y122DRFANyIEKVRIncA; Filament; DUF812; MPhosphoSitePlus
S60QVSRTsGGAGGAurB(Aurora BRegPhos
Y363SEASGyQDNIAFilament; Myosin_tail_1; PhosphoSitePlus
Y155RVAELyEEELRIncA; Filament; DUF812; MPhosphoSitePlus
S12SSQRVsSYRRTAurora BphosphoELM
Y5_MSQAySSSQRPhosphoSitePlus
S12SSQRVsSYRRTAURKBHPRD
T79LGTTRtPSSYGFilament_head; IncA; DUF8PhosphoSitePlus
T76ASRLGtTRTPSFilament_head; IncA; DUF8PhosphoSitePlus
S81TTRTPsSYGAGFilament_head; IncA; DUF8PhosphoSitePlus
S60QVSRTsGGAGGFilament_headPhosphoSitePlus
T422NLPIQtYSALNGAS; Spc7; IncAPhosphoSitePlus
T77SRLGTtRTPSSROCK1HPRD; RegPhos
Y54VTSRVyQVSRTHPRD
T450TVMIKtIETRDHPRD
S68AGGLGsLRASRFilament_head; IncAPhosphoSitePlus
Y405VEIATyRKLLEFilament; Myosin_tail_1; PhosphoSitePlus
T17SSYRRtFGGAPAurora BphosphoELM
Y331HQIQSyTCEIDFilament; Myosin_tail_1; PhosphoSitePlus
S330RHQIQsYTCEIFilament; Myosin_tail_1; PhosphoSitePlus
T76ASRLGtTRTPSROCK1HPRD; RegPhos
S424PIQTYsALNFRGAS; IncAPhosphoSitePlus
S60QVSRTsGGAGGAurora BphosphoELM
S68AGGLGsLRASRHPRD
T59YQVSRtSGGAGFilament_headPhosphoSitePlus
T17SSYRRtFGGAPROCK_groupphosphoELM; RegPhos
Y324QEMMEyRHQIQFilament; Myosin_tail_1; PhosphoSitePlus
S6MSQAYsSSQRVPhosphoSitePlus
Y296EAEEWyKSKVSFilament; Myosin_tail_1; PhosphoSitePlus
Y423LPIQTySALNFGAS; Spc7; IncAPhosphoSitePlus
S82TRTPSsYGAGEFilament_head; IncA; DUF8PhosphoSitePlus
S60QVSRTsGGAGGAURKBHPRD
S12SSQRVsSYRRTAurBRegPhos

Dephosphorylation site
DESM_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363071F356ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000363071V459ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000363071V459ITCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000363071F356ITCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363071hepatitis C virusNormal vs. CancertissueUp3.918715028
ENSP00000363071colorectal cancerNormal vs. CancertissueDown0.2314997500
ENSP00000363071colorectal cancerNormal vs. CancertissueDown0.314997500
ENSP00000363071Esophageal CancerNormal vs. CancertissueDown0.4519142970
ENSP00000363071Esophageal CancerNormal vs. CancertissueUp2.119142970
ENSP00000363071Esophageal CancerNormal vs. CancertissueUp2.619142970
ENSP00000363071breast ductal carcinomaNormal vs. CancertissueDown18564057
ENSP00000363071Pancreatic CancerNormal vs. CancertissueDown0.3315526344
ENSP00000363071Esophageal CancerNormal vs. CancertissueDown0.4716400690

Hyperphosphorylation site
DESM_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANDESM_HUMANkinase -> substrateRegPhos
AURKB_HUMANDESM_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05412Arrhythmogenic right ventricular cardiomyopathy (A
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05414Dilated cardiomyopathy

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0031594neuromuscular junctionIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007010cytoskeleton organizationTASbiological_process
GO:0005916fascia adherensIEAcellular_component
GO:0005882intermediate filamentIEAcellular_component
GO:0008092cytoskeletal protein bindingIPImolecular_function
GO:0042383sarcolemmaIEAcellular_component
GO:0008016regulation of heart contractionTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0043292contractile fiberIEAcellular_component
GO:0006936muscle contractionTASbiological_process
GO:0030049muscle filament slidingTASbiological_process
GO:0030018Z discIEAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0030018Z discIDAcellular_component