Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MYPT1_HUMAN
Description:protein phosphatase 1, regulatory subunit 12A [Source:HGNC Symbol;Acc:7618]
Location:chr12 q21.31
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S680DEESEsQRKARPhosphoSitePlus
Y669ERRRSyLTPVRPhosphoSitePlus
T22WIGSEtDLEPPPhosphoSitePlus
S588QKSLLsSTSTTHPRD
T696QSRRStQGVTLDMPK1RegPhos
S477SSPRLsSSLDNPhosphoSitePlus; HPRD; phosphoELM
S811ITSAYsRGITKPhosphoSitePlus
S432ERKDEsPATWRPhosphoSitePlus
S668RERRRsYLTPVPhosphoSitePlus; HPRD; SysPTM
T500AYVAPtIPRRLPhosphoSitePlus
S893SRYETsSTSAGPhosphoSitePlus
S578TPTVTsAAGLQPhosphoSitePlus
T590SLLSStSTTTKHPRD
T645NAAAStTTLTTPhosphoSitePlus
S695RQSRRsTQGVTPhosphoSitePlus; HPRD
T647AASTTtLTTTTPhosphoSitePlus
Y766TYDETyQRYRPPhosphoSitePlus
T443LGLRKtGSYGAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T702QGVTLtDLQEAPhosphoSitePlus
S547SVNEGsTYHKSPhosphoSitePlus
S877DTEEGsNKKETPhosphoSitePlus
T671RRSYLtPVRDEPhosphoSitePlus
S903GDRYDsLLGRSPhosphoSitePlus
S794SSLYAsSQLNRPhosphoSitePlus
T873EQQSDtEEGSNPhosphoSitePlus; HPRD; phosphoELM
T406SSGQAtPTSPIPhosphoSitePlus
T892ISRYEtSSTSAPhosphoSitePlus
S1029VISKLsK____PhosphoSitePlus
T853EKRRStGVSFWPhosphoSitePlus; SysPTM
S910LGRSGsYSYLEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T652TLTTTtAGTVSPhosphoSitePlus
T571SVPSTtSTPTVPhosphoSitePlus
S839KSQPKsIRERRPhosphoSitePlus
T696QSRRStQGVTLDMPKHPRD
S304SPLIEsTANMDPhosphoSitePlus
S566DLISSsVPSTTRegPhos
S20KRWIGsETDLEPhosphoSitePlus
T464QKEKDtAGVTRPhosphoSitePlus
Y920EERKPySSRLEPhosphoSitePlus
Y754SREDEyKQKYSPhosphoSitePlus
S478SPRLSsSLDNKPhosphoSitePlus; HPRD; phosphoELM
T631VPTAVtIPVAPPhosphoSitePlus
Y890DSISRyETSSTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S520ENRDSsSLRTSPhosphoSitePlus
S995LERRIsEMEEEPhosphoSitePlus
S912RSGSYsYLEERPhosphoSitePlus
S678VRDEEsESQRKPhosphoSitePlus
S445LRKTGsYGALAPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S790STMSSsLYASSPhosphoSitePlus
Y446RKTGSyGALAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S507PRRLAsTSDIEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S554YHKSCsFGRRQPhosphoSitePlus
S585AGLQKsLLSSTHPRD
S479PRLSSsLDNKEPhosphoSitePlus
T884KKETQtDSISRPhosphoSitePlus
T761QKYSRtYDETYPhosphoSitePlus
Y758EYKQKySRTYDPhosphoSitePlus
Y549NEGSTyHKSCSPhosphoSitePlus
S198VRHAKsGGTALHPRD
S716IGRSRsTRTREPhosphoSitePlus
T417KKFPTtATKISPhosphoSitePlus; HPRD; phosphoELM
T529TSSSYtRRKWEPhosphoSitePlus
Y68GADINyANVDGAnk_2PhosphoSitePlus
T717GRSRStRTREQPhosphoSitePlus
S856RSTGVsFWTQDPhosphoSitePlus; HPRD; SysPTM
Y496GTRLAyVAPTIPhosphoSitePlus; HPRD
S871EQEQQsDTEEGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S569SSSVPsTTSTPRegPhos
S795SLYASsQLNRPPhosphoSitePlus
S852REKRRsTGVSFPhosphoSitePlus
T696QSRRStQGVTLMRCKa(CDC42BPRegPhos
S894RYETSsTSAGDPhosphoSitePlus
T696QSRRStQGVTLPhosphoSitePlus; phosphoELM
S802LNRPNsLVGITPhosphoSitePlus
S472VTRSAsSPRLSPhosphoSitePlus
S852REKRRsTGVSFROCK1RegPhos
S470AGVTRsASSPRPhosphoSitePlus
S409QATPTsPIKKFPhosphoSitePlus
T593SSTSTtTKITTHPRD
T748KKESEtSREDEPhosphoSitePlus
S921ERKPYsSRLEKPhosphoSitePlus
S749KESETsREDEYPhosphoSitePlus
T305PLIEStANMDNHPRD
T575TTSTPtVTSAAPhosphoSitePlus
S541DLKKNsSVNEGPhosphoSitePlus
T453ALAEItASKEGPhosphoSitePlus
Y810GITSAySRGITPhosphoSitePlus
S607SAGTQsSTSNRPhosphoSitePlus
S759YKQKYsRTYDEPhosphoSitePlus
S422TATKIsPKEEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S781SSTTPsSSLSTPhosphoSitePlus
S473TRSASsPRLSSPhosphoSitePlus; HPRD; phosphoELM
T548VNEGStYHKSCPhosphoSitePlus
T859GVSFWtQDSDEPhosphoSitePlus; HPRD; SysPTM
T573PSTTStPTVTSPhosphoSitePlus
S299KRDKKsPLIESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T508RRLAStSDIEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S896ETSSTsAGDRYPhosphoSitePlus
Y911GRSGSySYLEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S509RLASTsDIEEKPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y936DFKKLyEQILAPhosphoSitePlus; HPRD
T700STQGVtLTDLQPhosphoSitePlus
S525SSLRTsSSYTRPhosphoSitePlus
T710QEAEKtIGRSRPhosphoSitePlus
S888QTDSIsRYETSPhosphoSitePlus; HPRD
S692RQARQsRRSTQPhosphoSitePlus
S542LKKNSsVNEGSPhosphoSitePlus
S862FWTQDsDENEQPhosphoSitePlus; HPRD; phosphoELM
S922RKPYSsRLEKDPhosphoSitePlus
T419FPTTAtKISPKPhosphoSitePlus
Y901SAGDRyDSLLGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T696QSRRStQGVTLILKHPRD; RegPhos
Y792MSSSLyASSQLPhosphoSitePlus
Y913SGSYSyLEERKPhosphoSitePlus
T696QSRRStQGVTLROCK1HPRD; phosphoELM; RegPhos
S552STYHKsCSFGRPhosphoSitePlus
Y762KYSRTyDETYQPhosphoSitePlus
S886ETQTDsISRYEPhosphoSitePlus
S908SLLGRsGSYSYPhosphoSitePlus; HPRD
T853EKRRStGVSFWROCK2HPRD; RegPhos; SysPTM
T853EKRRStGVSFWROCK1HPRD; RegPhos; SysPTM
T765RTYDEtYQRYRPhosphoSitePlus
S313MDNNQsQKTFKPhosphoSitePlus

Dephosphorylation site
MYPT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261207T646RCOSMICOvarian Cancer21720365
ENSP00000389168D83NBIOMARTBreast Cancer21930507, 21930502
ENSP00000261207T598MCOSMICIntestines Cancer17932254
ENSP00000261207R428KCOSMICMelanoma
ENSP00000261207D83NBIOMARTBreast Cancer21930507, 21930502
ENSP00000389168Q767HCOSMICBreast Cancer
ENSP00000261207I276TCOSMICOvarian Cancer21720365
ENSP00000261207Q767HCOSMICBreast Cancer
ENSP00000389168T598MCOSMICIntestines Cancer17932254
ENSP00000389168R428KCOSMICMelanoma
ENSP00000389168T646RCOSMICOvarian Cancer21720365
ENSP00000389168I276TCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261207Hepatocellular CarcinomaMetastasiscell lineUp2.119016532

Hyperphosphorylation site
MYPT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ROCK1_HUMANMYPT1_HUMANkinase -> substrateRegPhos
ILK_HUMANMYPT1_HUMANkinase -> substrateHPRD; RegPhos
DMPK_HUMANMYPT1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANMYPT1_HUMANkinase -> substrateRegPhos
ROCK2_HUMANMYPT1_HUMANkinase -> substrateHPRD; RegPhos
MYPT1_HUMANML12B_HUMANphosphatase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04720Long-term potentiation
hsa04270Vascular smooth muscle contraction
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionNASbiological_process
GO:0030155regulation of cell adhesionIDAbiological_process
GO:0051297centrosome organizationIMPbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0004857enzyme inhibitor activityIDAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007067mitosisIMPbiological_process
GO:0019208phosphatase regulator activityIMPmolecular_function
GO:0000776kinetochoreIDAcellular_component
GO:0072357PTW/PP1 phosphatase complexIDAcellular_component
GO:0043292contractile fiberIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0046822regulation of nucleocytoplasmic transportIEAbiological_process
GO:0043086negative regulation of catalytic activityIDAbiological_process
GO:0004871signal transducer activityNASmolecular_function
GO:007188914-3-3 protein bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006470protein dephosphorylationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0035507regulation of myosin-light-chain-phosphatase activIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23