Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PP1G_HUMAN
Description:protein phosphatase 1, catalytic subunit, gamma isozyme [Source:HGNC Symbol;Acc:9283]
Location:chr12 q24.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T318PRGMItKQAKKPhosphoSitePlus
T318PRGMItKQAKKNEK2RegPhos
T318PRGMItKQANEK2phosphoELM
Y137RIYGFyDECKRMetallophosPhosphoSitePlus
T311ATRPVtPPRGMPhosphoSitePlus
T307KKPNAtRPVTPNEK2phosphoELM; RegPhos; SysPTM
Y134SINRIyGFYDEMetallophosPhosphoSitePlus
S129NHECAsINRIYMetallophosPhosphoSitePlus
Y255VVEDGyEFFAKPhosphoSitePlus
T307KKPNAtRPVTPPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
PP1G_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000335084T307MCOSMICLung Cancer20668451
ENSP00000335084A306SCOSMICLung Cancer20668451

Differential expressed protein
PP1G_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PP1G_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK2_HUMANPP1G_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04114Oocyte meiosis
hsa04810Regulation of actin cytoskeleton
hsa04720Long-term potentiation
hsa04510Focal adhesion
hsa03015mRNA surveillance pathway
hsa04270Vascular smooth muscle contraction
hsa04728Dopaminergic synapse
hsa05168Herpes simplex infection
hsa05031Amphetamine addiction
hsa05034Alcoholism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0043234protein complexIMPcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0072357PTW/PP1 phosphatase complexIDAcellular_component
GO:0006629lipid metabolic processTASbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0030496midbodyIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0070688MLL5-L complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0004721phosphoprotein phosphatase activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0032154cleavage furrowIEAcellular_component
GO:0005977glycogen metabolic processIEAbiological_process
GO:0004722protein serine/threonine phosphatase activityIMPmolecular_function
GO:0006470protein dephosphorylationIEAbiological_process
GO:0019433triglyceride catabolic processTASbiological_process
GO:0016607nuclear speckIEAcellular_component
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0046822regulation of nucleocytoplasmic transportIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0051301cell divisionIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0004722protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005730nucleolusIDAcellular_component


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