Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NDC80_HUMAN
Description:NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:16909]
Location:chr18 p11.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T502KRSVRtLKEEVProminin; SlyXPhosphoSitePlus
S66TSGHGsRNSQLHPRD
S62FGKRTsGHGSRNdc80_HECPhosphoSitePlus
Y458YRAQVyVPLKEPhosphoSitePlus
T49SINKPtSERKVNdc80_HECPhosphoSitePlus
S69HGSRNsQLGIFHPRD
S62FGKRTsGHGSRHPRD; phosphoELM; RegPhos
S55SERKVsLFGKRNdc80_HECPhosphoSitePlus
S165YPFALsKSSMYNdc80_HEC; Cluap1PhosphoSitePlus
Y361IDNQKySVADIReo_sigmaC; SlyXPhosphoSitePlus
S55SERKVsLFGKRHPRD; phosphoELM; RegPhos
S77GIFSSsEKIKDNdc80_HECPhosphoSitePlus
S69HGSRNsQLGIFNdc80_HECPhosphoSitePlus
S76LGIFSsSEKIKHPRD; phosphoELM; RegPhos
T34LYTPQtKEKPTHPRD
S595ATHVGsVEKHLProminin; DUF1664PhosphoSitePlus
T591LEMVAtHVGSVProminin; DUF1664PhosphoSitePlus
S5_MKRSsVSSGGPhosphoSitePlus
S165YPFALsKSSMYNEK2HPRD; phosphoELM; RegPhos
S76LGIFSsSEKIKNdc80_HECPhosphoSitePlus
Y30NKQGLyTPQTKPhosphoSitePlus
S50INKPTsERKVSHPRD
S44TFGKLsINKPTPhosphoSitePlus; HPRD
S15GAGRLsMQELRPhosphoSitePlus
T31KQGLYtPQTKEPhosphoSitePlus; HPRD
S77GIFSSsEKIKDHPRD; phosphoELM; RegPhos

Dephosphorylation site
NDC80_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261597D628fs*9COSMICOvarian Cancer21720365

Differential expressed protein
NDC80_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NDC80_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK2_HUMANNDC80_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANNDC80_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
NDC80_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000776kinetochoreIDAcellular_component
GO:0008608attachment of spindle microtubules to kinetochoreIMPbiological_process
GO:0007052mitotic spindle organizationIMPbiological_process
GO:0000775chromosome, centromeric regionTAScellular_component
GO:0005634nucleusTAScellular_component
GO:0007059chromosome segregationIMPbiological_process
GO:0000777condensed chromosome kinetochoreIDAcellular_component
GO:0000942condensed nuclear chromosome outer kinetochoreIDAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0048015phosphatidylinositol-mediated signalingNASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0007049cell cycleNASbiological_process
GO:0007067mitosisTASbiological_process
GO:0000132establishment of mitotic spindle orientationIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0000070mitotic sister chromatid segregationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016020membraneIEAcellular_component
GO:0031262Ndc80 complexIDAcellular_component
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0016192vesicle-mediated transportIEAbiological_process
GO:0007051spindle organizationNASbiological_process


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