Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SUFU_HUMAN
Description:suppressor of fused homolog (Drosophila) [Source:HGNC Symbol;Acc:16466]
Location:chr10 q24.32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T305LSGKDtEQIRESUFU_CPhosphoSitePlus
S481DVVFDsPHPRD; phosphoELM
S346PSRKDsLESDSSUFU_CPhosphoSitePlus
S301QPRRLsGKDTESUFU_CPhosphoSitePlus
S290DEDSRsICIGTSUFU_CPhosphoSitePlus
T353ESDSStAIIPHSUFU_CPhosphoSitePlus
T21PAPGPtAPPAFPhosphoSitePlus
S481DVVFDsPLH__PhosphoSitePlus
T13GAPGPtAPPAPPhosphoSitePlus
S342HDRAPsRKDSLSUFU_CPhosphoSitePlus
S349KDSLEsDSSTASUFU_CPhosphoSitePlus

Dephosphorylation site
SUFU_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358918R299QCOSMICBreast Cancer20668451
ENSP00000358918R362CCOSMICCentral Nervous System Neoplasms21325292
ENSP00000358918P15LOMIMNeoplasms by Histologic Type12068298
ENSP00000358918R146*COSMICCentral Nervous System Neoplasms16567768
ENSP00000358918P187LCOSMICSkin Cancer15656799
ENSP00000358915*434YCOSMICOvarian Cancer20826764

Differential expressed protein
SUFU_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SUFU_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K19_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)
RPKL1_HUMANSUFU_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SUFU_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0008134transcription factor bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004871signal transducer activityTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0021513spinal cord dorsal/ventral patterningIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0001501skeletal system developmentTASbiological_process
GO:0042992negative regulation of transcription factor importTASbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0007275multicellular organismal developmentTASbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0042994cytoplasmic sequestering of transcription factorIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0043433negative regulation of sequence-specific DNA bindiTASbiological_process
GO:0006508proteolysisTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0045668negative regulation of osteoblast differentiationTASbiological_process
GO:0005929ciliumIEAcellular_component
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0045879negative regulation of smoothened signaling pathwaTASbiological_process


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