Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GCFC1_HUMAN
Description:PAX3 and PAX7 binding protein 1 [Source:HGNC Symbol;Acc:13579]
Location:chr21 q22.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y718KLINGyPSVVNGCFCPhosphoSitePlus
S158NSSAEsEQPLDPhosphoSitePlus; HPRD; phosphoELM
S295IGIEGsDDDALPhosphoSitePlus; HPRD
Y855ENFCRyLVHLAGCFCPhosphoSitePlus
S155TELNSsAESEQPhosphoSitePlus; HPRD; phosphoELM
T378TVPFKtPSNEMPhosphoSitePlus; HPRD
S557HLEGLsSDDEEHPRD; phosphoELM
S154KTELNsSAESEPhosphoSitePlus; HPRD; phosphoELM
S557HLEGLsSDDEEGCFCPhosphoSitePlus
S191EMDMEsEKEEEPhosphoSitePlus; HPRD
Y855ENFCRyLVHLAHPRD
T729AENKNtQVYLKGCFCPhosphoSitePlus
S380PFKTPsNEMTPHPRD
Y476AIHQLyKQRASGCFCPhosphoSitePlus
S16RKRNDsEEEERPhosphoSitePlus; HPRD; phosphoELM
T387EMTPVtIDLVKHPRD
Y521RDRALyQEHAKGCFCPhosphoSitePlus
S558LEGLSsDDEETHPRD; phosphoELM
S62LGPGPsPPSALPhosphoSitePlus; HPRD; phosphoELM
S108RASLLsFQDEEPhosphoSitePlus
T150KSKIKtELNSSPhosphoSitePlus
S558LEGLSsDDEETGCFCPhosphoSitePlus
S262DENDAsDDEDDPhosphoSitePlus; HPRD; phosphoELM
T563SDDEEtSTDITHPRD; phosphoELM

Dephosphorylation site
GCFC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000328992I219MCOSMICOvarian Cancer21720365
ENSP00000328992D747NCOSMICHead and Neck Cancer21798893
ENSP00000328992S720ACOSMICOvarian Cancer21720365

Differential expressed protein
GCFC1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GCFC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KC1G1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TBK1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
RIOK1_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
NEK3_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
BMX_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
SCYL2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TTK_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
PDK3_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
GCFC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005829cytosolIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0003677DNA bindingNASmolecular_function


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