Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDK3_HUMAN
Description:pyruvate dehydrogenase kinase, isozyme 3 [Source:HGNC Symbol;Acc:8811]
Location:chrX p22.11
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S239VVYVPsHLFHMHATPase_cPhosphoSitePlus
T169LINQHtLLFGGPhosphoSitePlus
Y19KQIERySRFSPPhosphoSitePlus

Dephosphorylation site
PDK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387536V193MTCGAOvarian Cancer21720365, 18772890
ENSP00000368460S362*Greenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000368460M126IBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000368460E219AGreenman2007, HPIHead and Neck Cancer17344846, 18428421

Differential expressed protein
PDK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDK3_HUMANODPA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PDK3_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PDK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006006glucose metabolic processIEAbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0010510regulation of acetyl-CoA biosynthetic process fromIMPbiological_process
GO:0071333cellular response to glucose stimulusISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0071398cellular response to fatty acidIMPbiological_process
GO:2000377regulation of reactive oxygen species metabolic prIMPbiological_process
GO:0010906regulation of glucose metabolic processIMPbiological_process
GO:0035357peroxisome proliferator activated receptor signaliIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0097411hypoxia-inducible factor-1alpha signaling pathwayIMPbiological_process
GO:0005739mitochondrionTAScellular_component
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinasIDAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0006090pyruvate metabolic processTASbiological_process
GO:0005759mitochondrial matrixTAScellular_component


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