Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TTK_HUMAN
Description:TTK protein kinase [Source:HGNC Symbol;Acc:12401]
Location:chr6 q14.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T12SGRELtIDSIMPhosphoSitePlus
S80NSVPLsDALLNHPRD; SysPTM
Y836TLYEHySGGESPhosphoSitePlus
T288DCDVKtDDSVVPhosphoSitePlus
T805QMAKGtTEEMKPhosphoSitePlus
S265VNLLNsPDCDVphosphoELM
S821LVGLNsPNSILPhosphoSitePlus; HPRD; SysPTM
S321PSGNDsCELRNPhosphoSitePlus; HPRD; SysPTM
T453KSICKtPSSNTPhosphoSitePlus
S433PVFSVsKQSPPHPRD
Y462NTLDDyMSCFRPhosphoSitePlus
S214LTAQEsFSGSLPhosphoSitePlus
T17KNEDLtDELSLphosphoELM
T675QMQPDtTSVVKPkinasePhosphoSitePlus
S37LTDELsLNKISPhosphoSitePlus; HPRD
S742IINQIsKLHAIPkinasePhosphoSitePlus
S7ESEDLsGRELTPhosphoSitePlus; SysPTM
Y255DAEIGyRNSLRPhosphoSitePlus
S218ESFSGsLGHLQPhosphoSitePlus
T351SELIItDSITLPhosphoSitePlus; HPRD
S353LIITDsITLKNPhosphoSitePlus; HPRD
S49DTTDNsGTVNQHPRD
T849SSSSKtFEKKRPhosphoSitePlus
S345VSDEKsSELIIHPRD
S363NKTESsLLAKLPhosphoSitePlus
S847HNSSSsKTFEKPhosphoSitePlus
Y833AAKTLyEHYSGPhosphoSitePlus; HPRD
T360TLKNKtESSLLPhosphoSitePlus
S382PEVPEsNQKQWPhosphoSitePlus
T686DSQVGtVNYMPPkinasePhosphoSitePlus
T795YVQIQtHPVNQPhosphoSitePlus
T806MAKGTtEEMKYPhosphoSitePlus
S393QSKRKsECINQPhosphoSitePlus; HPRD; SysPTM
S436SVSKQsPPISTPhosphoSitePlus; HPRD; SysPTM
S455ICKTPsSNTLDPhosphoSitePlus; HPRD
S216AQESFsGSLGHPhosphoSitePlus
S808LNSPNsILKAAphosphoELM
S80NSVPLsDALLNMad3_BUB1_IPhosphoSitePlus; SysPTM
S3___MEsEDLSGPhosphoSitePlus
S439ICKTPsSNTLDphosphoELM
S821LYEHYsGGESHphosphoELM; SysPTM
T564EADNQtLDSYRPkinase; TubulinPhosphoSitePlus
Y374EETKEyQEPEVPhosphoSitePlus
S281VNLLNsPDCDVPhosphoSitePlus; HPRD; SysPTM
Y811TEEMKyVLGQLPhosphoSitePlus
S317PGSKPsGNDSCPhosphoSitePlus; HPRD; SysPTM
S618LKKKKsIDPWEPkinasePhosphoSitePlus
S362KNKTEsSLLAKPhosphoSitePlus
S824LNSPNsILKAAPhosphoSitePlus; HPRD
S305PSGNDsCELRNphosphoELM
S845ESHNSsSSKTFPhosphoSitePlus
S258IGYRNsLRQTNPhosphoSitePlus
S582KLQQHsDKIIRPkinase; TubulinPhosphoSitePlus
S7RELTHPRD; SysPTM
Y131DDARDyFQMARMad3_BUB1_IPhosphoSitePlus
T458TPSSNtLDDYMPhosphoSitePlus
T371AKLEEtKEYQEPhosphoSitePlus
S837LYEHYsGGESHPhosphoSitePlus
S677QPDTTsVVKDSPkinasePhosphoSitePlus
S15ELTIDsIMNKVPhosphoSitePlus
T468MSCFRtPVVKNPhosphoSitePlus
S805LVGLNsPNSILphosphoELM
T33KNEDLtDELSLPhosphoSitePlus; HPRD; SysPTM
T676MQPDTtSVVKDPkinasePhosphoSitePlus

Dephosphorylation site
TTK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358813D697YBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000358813S214*TCGAOvarian Cancer21720365, 18772890
ENSP00000358813T637RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
TTK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TTK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TTK_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)
TTK_HUMANIF2A_HUMANkinase -> substrateRobert H Newman (2013)
TTK_HUMANMD1L1_HUMANkinase -> substrateKEGG
TTK_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007052mitotic spindle organizationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004712protein serine/threonine/tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007094mitotic cell cycle spindle assembly checkpointTASbiological_process
GO:0008284positive regulation of cell proliferationTASbiological_process
GO:0005819spindleTAScellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0007051spindle organizationTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23