Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPHA3_HUMAN
Description:EPH receptor A3 [Source:HGNC Symbol;Acc:3387]
Location:chr3 p11.1
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y602VDPHTyEDPTQautocatalysis RegPhos
Y596PGLRTyVDPHTEphA3RegPhos
Y602VDPHTyEDPTQEPHA3HPRD
Y779DPEAAyTTRGGphosphoELM
Y596PGLRTyVDPHTautocatalysis RegPhos
Y779DPEAAyTTRGGEphA3phosphoELM; RegPhos
Y596PGLRTyVDPHTPhosphoSitePlus; phosphoELM
S294KCPPHsSTQEDGCC2_GCC3PhosphoSitePlus
T442PSPVLtIKKDRfn3PhosphoSitePlus
Y736ASGMKyLSDMGPkinase_TyrPhosphoSitePlus
Y742LSDMGyVHRDLPkinase_TyrPhosphoSitePlus
T781EAAYTtRGGKIPkinase_TyrPhosphoSitePlus
Y602VDPHTyEDPTQEphA3phosphoELM; RegPhos
Y937FTGVEySSCDTSAM_2PhosphoSitePlus
S768SDFGLsRVLEDPkinase_TyrPhosphoSitePlus
Y561LTVVIyVLIGRTM; Rax2PhosphoSitePlus
Y596PGLRTyVDPHTEPHA3HPRD
Y124TFNLYyMESDDEphrin_lbdPhosphoSitePlus
T432AVSITtNQAAPPhosphoSitePlus
Y779DPEAAyTTRGGEPHA3HPRD
T974IKALEtQSKNGPhosphoSitePlus
S497TNVTIsSLKPDfn3; Rax2PhosphoSitePlus
T601YVDPHtYEDPTPhosphoSitePlus
Y779DPEAAyTTRGGautocatalysisRegPhos
S976ALETQsKNGPVPhosphoSitePlus
Y779DPEAAyTTRGGPkinase_TyrPhosphoSitePlus
S498NVTISsLKPDTfn3; Rax2PhosphoSitePlus
Y123ETFNLyYMESDEphrin_lbdPhosphoSitePlus
Y701MIVTEyMENGSPkinase_TyrPhosphoSitePlus
T485QETSYtILRARfn3; Rax2PhosphoSitePlus
Y602VDPHTyEDPTQPhosphoSitePlus
Y937FTGVEySSCDTRegPhos
Y570GRFCGyKSKHGRax2PhosphoSitePlus

Dephosphorylation site
EPHA3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000337451N85SSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000337451G518LHPILung Cancer17344846
ENSP00000337451A435SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451T912STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000337451S449FGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000337451G766EGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000337451N85SBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000337451I621LBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000337451D832NBIOMARTBreast Cancer21930507, 21930502
ENSP00000337451D446YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000399926D469NBIOMARTBreast Cancer21930507, 21930502
ENSP00000337451T393KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451T660KHPILung Cancer16941478
ENSP00000337451S229YHPINon-small cell lung carcinoma17344846
ENSP00000337451R728LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451W250RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451K761NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451I621LSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000337451N379KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451T933MHPILung Cancer16941478
ENSP00000337451D678EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451L162QTCGAOvarian Cancer21720365, 18772890
ENSP00000337451I564NTCGAOvarian Cancer21720365, 18772890
ENSP00000337451G187RDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451F871VTCGAOvarian Cancer21720365, 18772890
ENSP00000337451T166NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451D806NSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000337451T37KSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000337451S229YGreenman2007Lung Cancer16140923, 17344846, 18428421
ENSP00000337451M269IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000337451V226FTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000337451T215MTCGAOvarian Cancer21720365, 18772890
ENSP00000337451D806NBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000337451T37KBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000337451F612IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000337451D469NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000337451Lung CancerNormal vs. CancertissueUp15626334

Hyperphosphorylation site
EPHA3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EFNA2_HUMANEPHA3_HUMANligand -> receptorHPMR
EFNA1_HUMANEPHA3_HUMANligand -> receptorHPMR
EFNA3_HUMANEPHA3_HUMANligand -> receptorHPMR
EFNA5_HUMANEPHA3_HUMANligand -> receptorHPMR
EPHA3_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANSRS10_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANEPHA3_HUMANkinase -> substrateRegPhos
EPHA3_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANANS1A_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANZAP70_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANEPHA3_HUMANkinase -> substrateHPRD
EPHA3_HUMANSTAT3_HUMANkinase -> substrateHPRD
EPHA3_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANGPBP1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANM3K8_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANEPHA3_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANLZTS1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANTRI36_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANPPP5_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04360Axon guidance

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007155cell adhesionIEAbiological_process
GO:0048013ephrin receptor signaling pathwayIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0010976positive regulation of neuron projection developmeIMPbiological_process
GO:0097156fasciculation of motor neuron axonISSbiological_process
GO:0005769early endosomeIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0010717regulation of epithelial to mesenchymal transitionISSbiological_process
GO:0051893regulation of focal adhesion assemblyIDAbiological_process
GO:0032956regulation of actin cytoskeleton organizationIDAbiological_process
GO:0032319regulation of Rho GTPase activityIDAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0005004GPI-linked ephrin receptor activityIDAmolecular_function
GO:0070507regulation of microtubule cytoskeleton organizatioIDAbiological_process
GO:0006915apoptotic processISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016477cell migrationISSbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0097155fasciculation of sensory neuron axonISSbiological_process
GO:0071300cellular response to retinoic acidIMPbiological_process
GO:0005003ephrin receptor activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process