| UniProt/SwissProt ID: | PBX2_HUMAN |
| Description: | pre-B-cell leukemia homeobox 2 [Source:HGNC Symbol;Acc:8633] |
| Location: | chrHSCHR6_MHC_MANN p |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S136 | EKGGGsAAAAA | PBC | PhosphoSitePlus |
| S159 | NSIEHsDYRSK | HPRD; phosphoELM | |
| T325 | TAVSVtQGGHS | PhosphoSitePlus | |
| S159 | NSIEHsDYRSK | PBC | PhosphoSitePlus |
| S151 | SGGGVsPDNSI | HPRD; phosphoELM; SysPTM | |
| S395 | GGQMYsPREMR | PhosphoSitePlus | |
| S105 | LSIRSsQEEEP | PBC | PhosphoSitePlus |
| S151 | SGGGVsPDNSI | PBC | PhosphoSitePlus; SysPTM |
| Y316 | EEANIyAVKTA | PhosphoSitePlus | |
| S105 | LSIRSsQEEEP | HPRD; phosphoELM | |
| S330 | TQGGHsRTSSP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S104 | GLSIRsSQEEE | HPRD | |
| Dephosphorylation site |
| PBX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364190 | A77V | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| PBX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PBX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDKL5_HUMAN | PBX2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | PBX2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PBX2_HUMAN | CO5A2_HUMAN | TF -> target gene | TRANSFAC |
| PBX2_HUMAN | UROK_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PBX2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0030326 | embryonic limb morphogenesis | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0009954 | proximal/distal pattern formation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005667 | transcription factor complex | IEA | cellular_component |
| GO:0008134 | transcription factor binding | IPI | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |