| UniProt/SwissProt ID: | CSTFT_HUMAN |
| Description: | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant [Source:HGNC Symbol;Acc:17086] |
| Location: | chr10 q21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S601 | PEQRQsILILK | PhosphoSitePlus | |
| S113 | APIIDsPYGDP | PhosphoSitePlus | |
| T320 | PRGPVtPGGLP | PhosphoSitePlus | |
| S563 | QPSSFsPGQSQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S561 | GSQPSsFSPGQ | PhosphoSitePlus; HPRD | |
| S567 | FSPGQsQVTPQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T198 | RKIHVtPLIPG | PhosphoSitePlus | |
| S205 | LIPGKsQSVSV | PhosphoSitePlus | |
| S557 | SKQGGsQPSSF | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| CSTFT_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000332444 | M140I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000332444 | V151F | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000332444 | G545E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000332444 | G502W | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| CSTFT_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CSTFT_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK4_HUMAN | CSTFT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDKL5_HUMAN | CSTFT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CSTFT_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006397 | mRNA processing | IEA | biological_process |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |