Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MMP2_HUMAN
Description:matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [Source:HGNC Symbol;Acc:7166]
Location:chr16 q12.2
Node attribute:PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S160TPLRFsRIHDGPeptidase_M10PhosphoSitePlus
S365YESCTsAGRSDPeptidase_M10; fn2PhosphoSitePlus
S369TSAGRsDGKMWPeptidase_M10; fn2PhosphoSitePlus
T377KMWCAtTANYDPeptidase_M10; fn2PhosphoSitePlus
T378MWCATtANYDDPeptidase_M10; fn2PhosphoSitePlus
Y360FLGNKyESCTSPeptidase_M10; fn2PhosphoSitePlus
T364KYESCtSAGRSHPRD
S362GNKYEsCTSAGPeptidase_M10; fn2PhosphoSitePlus
T364KYESCtSAGRSPeptidase_M10; fn2PhosphoSitePlus
T250NSCTDtGRSDGPeptidase_M10; fn2PhosphoSitePlus
T11ARGALtGPLRAPhosphoSitePlus
S246GKEYNsCTDTGPeptidase_M10; fn2PhosphoSitePlus

Dephosphorylation site
MMP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000219070Y302CCOSMICLung Cancer20668451
ENSP00000219070D622GCOSMICMelanoma19330028
ENSP00000219070A228TSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000219070G272DCOSMICLung Cancer
ENSP00000219070S644IHPIColorectal Cancer16959974
ENSP00000219070P84LCOSMICMelanoma19330028
ENSP00000219070A145VCOSMICRenal Cancer
ENSP00000219070R432SBIOMARTBreast Cancer21930507, 21930502
ENSP00000219070G299SCOSMICHead and Neck Cancer21798897
ENSP00000219070T498MSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000219070A228THPIColorectal Cancer16959974
ENSP00000219070T498MHPIColorectal Cancer16959974
ENSP00000219070V400LCOSMICOvarian Cancer21720365
ENSP00000219070S644ISjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000219070Brain CancerNormal vs. CancertissueUp2.918056677
ENSP00000219070Gastric CancerNormal vs. Cancercell lineDown0.1120812763
ENSP00000219070Gastric CancerNormal vs. Cancercell lineDown0.0420812763

Hyperphosphorylation site
MMP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MMP2_HUMANHBEGF_HUMANotherKEGG
P53_HUMANMMP2_HUMANTF -> target geneTRANSFAC
AP2A_HUMANMMP2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04912GnRH signaling pathway
hsa05200Pathways in cancer
hsa04670Leukocyte transendothelial migration
hsa05219Bladder cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0060346bone trabecula formationIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0001955blood vessel maturationIEAbiological_process
GO:0030017sarcomereIEAcellular_component
GO:0001957intramembranous ossificationIEAbiological_process
GO:0008237metallopeptidase activityIEAmolecular_function
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0022617extracellular matrix disassemblyTASbiological_process
GO:0007566embryo implantationIEAbiological_process
GO:0004252serine-type endopeptidase activityTASmolecular_function
GO:0004222metalloendopeptidase activityIEAmolecular_function
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006508proteolysisIEAbiological_process
GO:0030198extracellular matrix organizationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0030574collagen catabolic processIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0060325face morphogenesisIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0031012extracellular matrixIEAcellular_component


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