| UniProt/SwissProt ID: | K1C14_HUMAN |
| Description: | keratin 14 [Source:HGNC Symbol;Acc:6416] |
| Location: | chr17 q21.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T9 | CSRQFtSSSSM | PhosphoSitePlus | |
| S12 | QFTSSsSMKGS | PhosphoSitePlus | |
| S53 | GGLSVsSSRFS | PhosphoSitePlus | |
| Y204 | DFRTKyETELN | Filament; Myosin_tail_1; | PhosphoSitePlus |
| S32 | GSSRIsSVLAG | PhosphoSitePlus | |
| S429 | AHLSSsQFSSG | PhosphoSitePlus | |
| S332 | GKSEIsELRRT | Filament; DUF1664; Bacill | PhosphoSitePlus |
| Y165 | KDYSPyFKTIE | Filament; DUF3848; Myosin | PhosphoSitePlus |
| S321 | EVATNsELVQS | Filament; DUF1664; Bacill | PhosphoSitePlus |
| S17 | SSMKGsCGIGG | PhosphoSitePlus | |
| S433 | SSQFSsGSQSS | PhosphoSitePlus; HPRD | |
| S128 | NDRLAsYLDKV | Filament | PhosphoSitePlus |
| Y415 | QEIATyRRLLE | Filament | PhosphoSitePlus |
| T319 | NREVAtNSELV | Filament; DUF1664; Bacill | PhosphoSitePlus |
| S33 | SSRISsVLAGG | PhosphoSitePlus | |
| Y151 | KIRDWyQRQRP | Filament; DUF3848 | PhosphoSitePlus |
| S437 | SSGSQsSRDVT | PhosphoSitePlus | |
| S432 | SSSQFsSGSQS | PhosphoSitePlus | |
| Y46 | RAPSTyGGGLS | PhosphoSitePlus | |
| S44 | SCRAPsTYGGG | PhosphoSitePlus | |
| S28 | GIGGGsSRISS | PhosphoSitePlus | |
| S39 | VLAGGsCRAPS | PhosphoSitePlus | |
| S435 | QFSSGsQSSRD | PhosphoSitePlus; HPRD | |
| Y129 | DRLASyLDKVR | Filament | PhosphoSitePlus |
| S438 | SGSQSsRDVTS | PhosphoSitePlus; HPRD | |
| Y291 | EMRDQyEKMAE | Filament; DUF1664; Bacill | PhosphoSitePlus |
| S13 | FTSSSsMKGSC | PhosphoSitePlus | |
| Y398 | QQNQEyKILLD | Filament | PhosphoSitePlus |
| T45 | CRAPStYGGGL | PhosphoSitePlus | |
| Dephosphorylation site |
| K1C14_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000167586 | E360K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000167586 | Pancreatic Cancer | Normal vs. Cancer | tissue | Down | 0.05 | 16215274 | ENSP00000167586 | Esophageal Cancer | Normal vs. Cancer | tissue | Down | 0.47 | 19142970 | ENSP00000167586 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.1 | 19142970 | ENSP00000167586 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.3 | 19142970 | ENSP00000167586 | Esophageal Cancer | Normal vs. Cancer | tissue | Up | 2.4 | 19142970 | ENSP00000167586 | Oral Cancer | Normal vs. Cancer | tissue | Up | 7.3 | 19297561 | ENSP00000167586 | breast ductal carcinoma | Normal vs. Cancer | tissue | Down | 18564057 | ENSP00000167586 | Oral Cancer | Normal vs. Cancer | tissue | Up | 4.3 | 19691830 | ENSP00000167586 | Nonmelanoma | Normal vs. Cancer | cell line | Up | 2.7 | 19243805 | ENSP00000167586 | Uterine Cancer | Treatment(none vs. transfected with the pOP13 vector that containing E7) | cell line | Down | 14997504 |
| Hyperphosphorylation site |
| K1C14_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AP2A_HUMAN | K1C14_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| K1C14_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0071944 | cell periphery | IEA | cellular_component |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0045110 | intermediate filament bundle assembly | IMP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0045095 | keratin filament | IDA | cellular_component |
| GO:0005882 | intermediate filament | NAS | cellular_component |
| GO:0010212 | response to ionizing radiation | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0031581 | hemidesmosome assembly | TAS | biological_process |
| GO:0008544 | epidermis development | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010043 | response to zinc ion | IEA | biological_process |
| GO:0034329 | cell junction assembly | TAS | biological_process |
| GO:0030855 | epithelial cell differentiation | IEA | biological_process |