Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:K1C14_HUMAN
Description:keratin 14 [Source:HGNC Symbol;Acc:6416]
Location:chr17 q21.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T9CSRQFtSSSSMPhosphoSitePlus
S12QFTSSsSMKGSPhosphoSitePlus
S53GGLSVsSSRFSPhosphoSitePlus
Y204DFRTKyETELNFilament; Myosin_tail_1; PhosphoSitePlus
S32GSSRIsSVLAGPhosphoSitePlus
S429AHLSSsQFSSGPhosphoSitePlus
S332GKSEIsELRRTFilament; DUF1664; BacillPhosphoSitePlus
Y165KDYSPyFKTIEFilament; DUF3848; MyosinPhosphoSitePlus
S321EVATNsELVQSFilament; DUF1664; BacillPhosphoSitePlus
S17SSMKGsCGIGGPhosphoSitePlus
S433SSQFSsGSQSSPhosphoSitePlus; HPRD
S128NDRLAsYLDKVFilamentPhosphoSitePlus
Y415QEIATyRRLLEFilamentPhosphoSitePlus
T319NREVAtNSELVFilament; DUF1664; BacillPhosphoSitePlus
S33SSRISsVLAGGPhosphoSitePlus
Y151KIRDWyQRQRPFilament; DUF3848PhosphoSitePlus
S437SSGSQsSRDVTPhosphoSitePlus
S432SSSQFsSGSQSPhosphoSitePlus
Y46RAPSTyGGGLSPhosphoSitePlus
S44SCRAPsTYGGGPhosphoSitePlus
S28GIGGGsSRISSPhosphoSitePlus
S39VLAGGsCRAPSPhosphoSitePlus
S435QFSSGsQSSRDPhosphoSitePlus; HPRD
Y129DRLASyLDKVRFilamentPhosphoSitePlus
S438SGSQSsRDVTSPhosphoSitePlus; HPRD
Y291EMRDQyEKMAEFilament; DUF1664; BacillPhosphoSitePlus
S13FTSSSsMKGSCPhosphoSitePlus
Y398QQNQEyKILLDFilamentPhosphoSitePlus
T45CRAPStYGGGLPhosphoSitePlus

Dephosphorylation site
K1C14_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000167586E360KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000167586Pancreatic CancerNormal vs. CancertissueDown0.0516215274
ENSP00000167586Esophageal CancerNormal vs. CancertissueDown0.4719142970
ENSP00000167586Esophageal CancerNormal vs. CancertissueUp2.119142970
ENSP00000167586Esophageal CancerNormal vs. CancertissueUp2.319142970
ENSP00000167586Esophageal CancerNormal vs. CancertissueUp2.419142970
ENSP00000167586Oral CancerNormal vs. CancertissueUp7.319297561
ENSP00000167586breast ductal carcinomaNormal vs. CancertissueDown18564057
ENSP00000167586Oral CancerNormal vs. CancertissueUp4.319691830
ENSP00000167586NonmelanomaNormal vs. Cancercell lineUp2.719243805
ENSP00000167586Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504

Hyperphosphorylation site
K1C14_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AP2A_HUMANK1C14_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
K1C14_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0071944cell peripheryIEAcellular_component
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0045110intermediate filament bundle assemblyIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0045095keratin filamentIDAcellular_component
GO:0005882intermediate filamentNAScellular_component
GO:0010212response to ionizing radiationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0031581hemidesmosome assemblyTASbiological_process
GO:0008544epidermis developmentTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010043response to zinc ionIEAbiological_process
GO:0034329cell junction assemblyTASbiological_process
GO:0030855epithelial cell differentiationIEAbiological_process


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