| UniProt/SwissProt ID: | KLF12_HUMAN |
| Description: | Kruppel-like factor 12 [Source:HGNC Symbol;Acc:6346] |
| Location: | chr13 q22.1 |
| Node attribute: | TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S240 | QSKSDsDDDDL | PhosphoSitePlus | |
| T104 | SPVSMtASASS | PhosphoSitePlus | |
| S202 | YTAVRsPGNVN | PhosphoSitePlus | |
| S117 | STSTSsSSSSR | PhosphoSitePlus | |
| S102 | SSSPVsMTASA | PhosphoSitePlus | |
| T15 | IKNINtFENRM | PhosphoSitePlus | |
| T249 | DLPNVtLDSVN | PhosphoSitePlus | |
| T340 | KAHRRtHTGEK | zf-C2H2 | PhosphoSitePlus |
| S119 | STSSSsSSRLA | PhosphoSitePlus | |
| S273 | QEVHPsPVSRV | PhosphoSitePlus | |
| S92 | NKARTsPTAVS | PhosphoSitePlus | |
| T342 | HRRTHtGEKPY | PhosphoSitePlus | |
| T91 | INKARtSPTAV | PhosphoSitePlus | |
| S109 | TASASsPSSTS | PhosphoSitePlus | |
| S99 | TAVSSsPVSMT | PhosphoSitePlus | |
| Dephosphorylation site |
| KLF12_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000366897 | P166L | COSMIC | Skin Cancer | 21984974 | ENSP00000366897 | K335E | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| KLF12_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| KLF12_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KLF12_HUMAN | AP2A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KLF12_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003714 | transcription corepressor activity | TAS | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0006357 | regulation of transcription from RNA polymerase II | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |