Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADML_HUMAN
Description:adrenomedullin [Source:HGNC Symbol;Acc:259]
Location:chr11 p15.4
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S49RELRMsSSYPTAdrenomedullinPhosphoSitePlus
Y146ISPQGyGRRRRAdrenomedullinPhosphoSitePlus
Y125LAHQIyQFTDKAdrenomedullinPhosphoSitePlus

Dephosphorylation site
ADML_HUMAN do not have dephosphorylation site.

Mutation site
ADML_HUMAN do not have mutation site.

Differential expressed protein
ADML_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADML_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ADML_HUMANRAMP2_HUMANligand -> receptorHPMR
ADML_HUMANCALRL_HUMANligand -> receptorHPMR
ADML_HUMANMRGX2_HUMANligand -> receptorHPMR
ADML_HUMANGP182_HUMANligand -> receptorHPMR
AP2A_HUMANADML_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ADML_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0032868response to insulin stimulusIEAbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0006701progesterone biosynthetic processTASbiological_process
GO:0001570vasculogenesisIDAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0031700adrenomedullin receptor bindingIEAmolecular_function
GO:0097084vascular smooth muscle cell developmentIEAbiological_process
GO:0043116negative regulation of vascular permeabilityIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0008209androgen metabolic processIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0007267cell-cell signalingTASbiological_process
GO:2001214positive regulation of vasculogenesisIEAbiological_process
GO:0042594response to starvationIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIDAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0055074calcium ion homeostasisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005179hormone activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0006171cAMP biosynthetic processIDAbiological_process
GO:0060712spongiotrophoblast layer developmentIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0045906negative regulation of vasoconstrictionIDAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0010460positive regulation of heart rateIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0007565female pregnancyIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIEAbiological_process
GO:0009409response to coldIEAbiological_process
GO:0060670branching involved in labyrinthine layer morphogenIEAbiological_process
GO:0045909positive regulation of vasodilationIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0019933cAMP-mediated signalingIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0031102neuron projection regenerationIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0002026regulation of the force of heart contractionIEAbiological_process
GO:0046879hormone secretionIEAbiological_process
GO:0031623receptor internalizationIDAbiological_process
GO:0008015blood circulationTASbiological_process


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