| UniProt/SwissProt ID: | CO3_HUMAN |
| Description: | complement component 3 [Source:HGNC Symbol;Acc:1318] |
| Location: | chr19 p13.3 |
| Node attribute: | ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T885 | RRHQQtVTIPP | PhosphoSitePlus | |
| S1586 | QRTFIsPIKCR | HPRD | |
| S928 | DGVRKsLKVVP | PhosphoSitePlus | |
| S742 | QHARAsHLGLA | PhosphoSitePlus; phosphoELM | |
| S297 | PIEDGsGEVVL | PhosphoSitePlus; HPRD | |
| S283 | GEQRIsLPESL | A2M_N | PhosphoSitePlus |
| T1031 | HYLDEtEQWEK | PhosphoSitePlus; phosphoELM | |
| T676 | RSVQLtEKRMD | PhosphoSitePlus | |
| S1343 | GQGTLsVVTMY | PhosphoSitePlus | |
| Y686 | DKVGKyPKELR | PhosphoSitePlus | |
| S1571 | EQTIKsGSDEV | HPRD | |
| Y1194 | VAIAGyALAQM | A2M_comp | PhosphoSitePlus |
| S287 | ISLPEsLKRIP | A2M_N | PhosphoSitePlus |
| S1586 | QRTFIsPIKCR | NTR | PhosphoSitePlus |
| S1573 | TIKSGsDEVQV | HPRD | |
| S672 | ARRRRsVQLTE | PhosphoSitePlus | |
| S303 | GEVVLsRKVLL | PhosphoSitePlus | |
| S922 | YHHFIsDGVRK | PhosphoSitePlus | |
| Y1480 | GAVKVyAYYNL | A2M_recep | PhosphoSitePlus |
| Dephosphorylation site |
| CO3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000245907 | T654I | COSMIC | Skin Cancer | 21984974 | ENSP00000245907 | V886I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000245907 | P1251L | COSMIC | Melanoma | 21499247 | ENSP00000245907 | E1487K | COSMIC | Melanoma | 21499247 | ENSP00000245907 | G1132R | COSMIC | Skin Cancer | 21984974 | ENSP00000245907 | R834Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000245907 | S283F | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000245907 | R764Q | COSMIC | Melanoma | 21499247 | ENSP00000245907 | E1314K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000245907 | T1341N | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000245907 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3 | 18715028 | ENSP00000245907 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000245907 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000245907 | breast ductal carcinoma | Normal vs. Cancer | tissue | Down | 0.24 | 18401453 | ENSP00000245907 | Brain Cancer | Normal vs. Cancer | tissue | Up | 5.4 | 18056677 | ENSP00000245907 | Ovarian Cancer | Normal vs. Cancer | tissue | Down | 17137333 | ENSP00000245907 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 17137333 | ENSP00000245907 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 1.8 | 20162585 | ENSP00000245907 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 2.1 | 20162585 | ENSP00000245907 | Ovarian Cancer | Normal vs. Cancer | tissue | Up | 2.3 | 20162585 | ENSP00000245907 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 19471570 | ENSP00000245907 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 3 | 16739137 |
| Hyperphosphorylation site |
| CO3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CO3_HUMAN | LRP1_HUMAN | ligand -> receptor | HPMR |
| CO3_HUMAN | C3AR_HUMAN | ligand -> receptor | HPMR |
| ESR2_HUMAN | CO3_HUMAN | TF -> target gene | TRANSFAC |
| AP2A_HUMAN | CO3_HUMAN | TF -> target gene | TRANSFAC |
| ESR1_HUMAN | CO3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05142 | Chagas disease (American trypanosomiasis) |
| hsa05152 | Tuberculosis |
| hsa04145 | Phagosome |
| hsa05168 | Herpes simplex infection |
| hsa05150 | Staphylococcus aureus infection |
| hsa05134 | Legionellosis |
| hsa05322 | Systemic lupus erythematosus |
| hsa05133 | Pertussis |
| hsa04610 | Complement and coagulation cascades |
| hsa05140 | Leishmaniasis |
| hsa05203 | Viral carcinogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0010828 | positive regulation of glucose transport | IDA | biological_process |
| GO:0006957 | complement activation, alternative pathway | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0050766 | positive regulation of phagocytosis | IEA | biological_process |
| GO:0045087 | innate immune response | TAS | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0031715 | C5L2 anaphylatoxin chemotactic receptor binding | IDA | molecular_function |
| GO:0010866 | regulation of triglyceride biosynthetic process | IDA | biological_process |
| GO:0010575 | positive regulation vascular endothelial growth fa | IDA | biological_process |
| GO:0006955 | immune response | TAS | biological_process |
| GO:0001970 | positive regulation of activation of membrane atta | IEA | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0006956 | complement activation | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0045766 | positive regulation of angiogenesis | IEA | biological_process |
| GO:0045745 | positive regulation of G-protein coupled receptor | IDA | biological_process |
| GO:0006631 | fatty acid metabolic process | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006956 | complement activation | IEA | biological_process |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0001798 | positive regulation of type IIa hypersensitivity | IEA | biological_process |
| GO:0004866 | endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0030449 | regulation of complement activation | TAS | biological_process |
| GO:0006958 | complement activation, classical pathway | IEA | biological_process |
| GO:0010884 | positive regulation of lipid storage | IDA | biological_process |