Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CO3_HUMAN
Description:complement component 3 [Source:HGNC Symbol;Acc:1318]
Location:chr19 p13.3
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T885RRHQQtVTIPPPhosphoSitePlus
S1586QRTFIsPIKCRHPRD
S928DGVRKsLKVVPPhosphoSitePlus
S742QHARAsHLGLAPhosphoSitePlus; phosphoELM
S297PIEDGsGEVVLPhosphoSitePlus; HPRD
S283GEQRIsLPESLA2M_NPhosphoSitePlus
T1031HYLDEtEQWEKPhosphoSitePlus; phosphoELM
T676RSVQLtEKRMDPhosphoSitePlus
S1343GQGTLsVVTMYPhosphoSitePlus
Y686DKVGKyPKELRPhosphoSitePlus
S1571EQTIKsGSDEVHPRD
Y1194VAIAGyALAQMA2M_compPhosphoSitePlus
S287ISLPEsLKRIPA2M_NPhosphoSitePlus
S1586QRTFIsPIKCRNTRPhosphoSitePlus
S1573TIKSGsDEVQVHPRD
S672ARRRRsVQLTEPhosphoSitePlus
S303GEVVLsRKVLLPhosphoSitePlus
S922YHHFIsDGVRKPhosphoSitePlus
Y1480GAVKVyAYYNLA2M_recepPhosphoSitePlus

Dephosphorylation site
CO3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000245907T654ICOSMICSkin Cancer21984974
ENSP00000245907V886IBIOMARTBreast Cancer21930507, 21930502
ENSP00000245907P1251LCOSMICMelanoma21499247
ENSP00000245907E1487KCOSMICMelanoma21499247
ENSP00000245907G1132RCOSMICSkin Cancer21984974
ENSP00000245907R834QBIOMARTBreast Cancer21930507, 21930502
ENSP00000245907S283FCOSMICHead and Neck Cancer21984974
ENSP00000245907R764QCOSMICMelanoma21499247
ENSP00000245907E1314KCOSMICHead and Neck Cancer21984974
ENSP00000245907T1341NCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000245907hepatitis C virusNormal vs. CancertissueUp318715028
ENSP00000245907Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000245907Breast CancerNormal vs. CancertissueUp18257521
ENSP00000245907breast ductal carcinomaNormal vs. CancertissueDown0.2418401453
ENSP00000245907Brain CancerNormal vs. CancertissueUp5.418056677
ENSP00000245907Ovarian CancerNormal vs. CancertissueDown17137333
ENSP00000245907Ovarian CancerNormal vs. CancertissueUp17137333
ENSP00000245907Ovarian CancerNormal vs. CancertissueUp1.820162585
ENSP00000245907Ovarian CancerNormal vs. CancertissueUp2.120162585
ENSP00000245907Ovarian CancerNormal vs. CancertissueUp2.320162585
ENSP00000245907Uterine CancerNormal vs. CancertissueUp19471570
ENSP00000245907Pancreatic CancerNormal vs. CancertissueUp316739137

Hyperphosphorylation site
CO3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO3_HUMANLRP1_HUMANligand -> receptorHPMR
CO3_HUMANC3AR_HUMANligand -> receptorHPMR
ESR2_HUMANCO3_HUMANTF -> target geneTRANSFAC
AP2A_HUMANCO3_HUMANTF -> target geneTRANSFAC
ESR1_HUMANCO3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05152Tuberculosis
hsa04145Phagosome
hsa05168Herpes simplex infection
hsa05150Staphylococcus aureus infection
hsa05134Legionellosis
hsa05322Systemic lupus erythematosus
hsa05133Pertussis
hsa04610Complement and coagulation cascades
hsa05140Leishmaniasis
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0010828positive regulation of glucose transportIDAbiological_process
GO:0006957complement activation, alternative pathwayTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0050766positive regulation of phagocytosisIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005576extracellular regionTAScellular_component
GO:0005615extracellular spaceIEAcellular_component
GO:0031715C5L2 anaphylatoxin chemotactic receptor bindingIDAmolecular_function
GO:0010866regulation of triglyceride biosynthetic processIDAbiological_process
GO:0010575positive regulation vascular endothelial growth faIDAbiological_process
GO:0006955immune responseTASbiological_process
GO:0001970positive regulation of activation of membrane attaIEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0006956complement activationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0045745positive regulation of G-protein coupled receptor IDAbiological_process
GO:0006631fatty acid metabolic processIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006956complement activationIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0001798positive regulation of type IIa hypersensitivityIEAbiological_process
GO:0004866endopeptidase inhibitor activityIEAmolecular_function
GO:0030449regulation of complement activationTASbiological_process
GO:0006958complement activation, classical pathwayIEAbiological_process
GO:0010884positive regulation of lipid storageIDAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23