Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AKT3_HUMAN
Description:v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) [Source:HGNC Symbol;Acc:393]
Location:chr1 q44
Node attribute:PPI(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T298CKEGItDAATMPkinase_AGCPhosphoSitePlus
T305AATMKtFCGTPPkinase_AGCPhosphoSitePlus
Y473FPQFSySASGRPkinase_CPhosphoSitePlus
S120ERMNCsPTSQIPhosphoSitePlus; phosphoELM; RegPhos
T305AATMKtFCGTPPDK1RegPhos
Y312CGTPEyLAPEVPkinase_AGCPhosphoSitePlus
T305AATMKtFCGTPPRKCZHPRD
S474PQFSYsASGREPkinase_CPhosphoSitePlus
S472HFPQFsYSASGPRKCDHPRD
T447QTITItPPEKYphosphoELM; RegPhos
S472HFPQFsYSASGHPRD; phosphoELM; RegPhos
T447QTITItPPEKYPkinase_CPhosphoSitePlus
Y38GSFIGyKEKPQPHPhosphoSitePlus
T309KTFCGtPEYLAPkinase_AGCPhosphoSitePlus
S472HFPQFsYSASGPkinase_CPhosphoSitePlus
S476FSYSAsGRE__PhosphoSitePlus
S120ERMNCsPTSQIPDK1HPRD
S472HFPQFsYSASGPKCdRegPhos
S120ERMNCsPTSQIPDHK1RegPhos
S123NCSPTsQIDNIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T305AATMKtFCGTPPKCzRegPhos
Y434ETDTRyFDEEFPkinase_CPhosphoSitePlus
T440FDEEFtAQTITPkinase_CPhosphoSitePlus
T305AATMKtFCGTPPDPK1HPRD
T302ITDAAtMKTFCPkinase_AGCPhosphoSitePlus
T305AATMKtFCGTPPDK-1phosphoELM
Y323LEDNDyGRAVDPkinase_AGCPhosphoSitePlus
S197HTLTEsRVLKNPkinase_AGCPhosphoSitePlus
T432TSETDtRYFDEPkinase_CPhosphoSitePlus

Dephosphorylation site
AKT3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263826G171RHPINeoplasms by Histologic Type17344846
ENSP00000355497G171RGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000355497Q124LDing2008Lung Cancer18948947
ENSP00000355497G171RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421

Differential expressed protein
AKT3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AKT3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANAKT3_HUMANkinase -> substrateRegPhos
PDK1_HUMANAKT3_HUMANkinase -> substrateRegPhos
ILK_HUMANAKT3_HUMANkinase -> substrateKEGG
AKT3_HUMANPDE3A_HUMANkinase -> substrateKEGG
FAK2_HUMANAKT3_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANMTOR_HUMANkinase -> substrateKEGG
PDPK1_HUMANAKT3_HUMANkinase -> substrateKEGG; HPRD; RegPhos
AKT3_HUMANM3K5_HUMANkinase -> substrateKEGG
AKT3_HUMANAKTS1_HUMANkinase -> substrateKEGG
AKT3_HUMANM3K8_HUMANkinase -> substrateKEGG
KPCZ_HUMANAKT3_HUMANkinase -> substrateHPRD
TGFR2_HUMANAKT3_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANBAD_HUMANkinase -> substrateKEGG
PI3R5_HUMANAKT3_HUMANkinase -> substrateKEGG
AKT3_HUMANNOS3_HUMANkinase -> substrateKEGG
AKT3_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANGSK3B_HUMANkinase -> substrateKEGG
AKT3_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANMP2K4_HUMANkinase -> substrateKEGG
AKT3_HUMANFOXO1_HUMANkinase -> substrateKEGG
AKT3_HUMANCDN1A_HUMANkinase -> substrateKEGG
KPCD_HUMANAKT3_HUMANkinase -> substrateHPRD
AKT3_HUMANSYFM_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANTSC2_HUMANkinase -> substrateKEGG
MTOR_HUMANAKT3_HUMANkinase -> substrateKEGG
AKT3_HUMANCASP9_HUMANkinase -> substrateKEGG
AKT3_HUMANCDN1B_HUMANkinase -> substrateKEGG
PTEN_HUMANAKT3_HUMANotherKEGG
PI3R5_HUMANAKT3_HUMANotherKEGG
AKT3_HUMANPP1A_HUMANotherKEGG
PDPK1_HUMANAKT3_HUMANotherKEGG
AKT3_HUMANGTR4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa05222Small cell lung cancer
hsa04150mTOR signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04510Focal adhesion
hsa04662B cell receptor signaling pathway
hsa05164Influenza A
hsa05212Pancreatic cancer
hsa05223Non-small cell lung cancer
hsa04910Insulin signaling pathway
hsa04062Chemokine signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05162Measles
hsa05200Pathways in cancer
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05220Chronic myeloid leukemia
hsa05169Epstein-Barr virus infection
hsa04664Fc epsilon RI signaling pathway
hsa04210Apoptosis
hsa04920Adipocytokine signaling pathway
hsa04530Tight junction
hsa05221Acute myeloid leukemia
hsa04666Fc gamma R-mediated phagocytosis
hsa05214Glioma
hsa04914Progesterone-mediated oocyte maturation
hsa05166HTLV-I infection
hsa04973Carbohydrate digestion and absorption
hsa05160Hepatitis C
hsa05145Toxoplasmosis
hsa04722Neurotrophin signaling pathway
hsa04660T cell receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04010MAPK signaling pathway
hsa05152Tuberculosis
hsa05215Prostate cancer
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa04380Osteoclast differentiation
hsa04370VEGF signaling pathway
hsa04012ErbB signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0000002mitochondrial genome maintenanceIMPbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0007165signal transductionIMPbiological_process
GO:0006468protein phosphorylationTASbiological_process