| UniProt/SwissProt ID: | PDE3A_HUMAN |
| Description: | phosphodiesterase 3A, cGMP-inhibited [Source:HGNC Symbol;Acc:8778] |
| Location: | chr12 p12.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S463 | VRRDRsTSIKL | PhosphoSitePlus | |
| S301 | VSAEMsGCSSK | PhosphoSitePlus | |
| S528 | SSPCSsPLQGT | PhosphoSitePlus | |
| S312 | SHRRTsLPCIP | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S438 | LLRRVsSTWTT | PhosphoSitePlus | |
| T615 | RTPSRtDDTAQ | HPRD | |
| T643 | QNEDEtECLRE | PhosphoSitePlus | |
| S465 | RDRSTsIKLQE | PhosphoSitePlus | |
| S613 | ATRTPsRTDDT | PhosphoSitePlus | |
| S478 | SSSPDsWNNPV | PhosphoSitePlus | |
| T442 | VSSTWtTTTSA | PhosphoSitePlus | |
| S408 | ENYTCsDSEES | PhosphoSitePlus; HPRD; phosphoELM | |
| S575 | SAPDLsPQILT | PhosphoSitePlus | |
| T444 | STWTTtTSATG | PhosphoSitePlus | |
| S527 | LSSPCsSPLQG | PhosphoSitePlus | |
| S550 | VQFPEsADTTA | PhosphoSitePlus | |
| S475 | EAPSSsPDSWN | HPRD | |
| S492 | LTKSRsFTSSY | PhosphoSitePlus; HPRD | |
| T580 | SPQILtPPVIC | PhosphoSitePlus | |
| S439 | LRRVSsTWTTT | PhosphoSitePlus | |
| S524 | ISPLSsPCSSP | PhosphoSitePlus | |
| S523 | KISPLsSPCSS | PhosphoSitePlus | |
| T443 | SSTWTtTTSAT | PhosphoSitePlus | |
| T533 | SPLQGtPASSL | PhosphoSitePlus | |
| S410 | YTCSDsEESSE | HPRD; phosphoELM | |
| S294 | RRRSSsVVSAE | PhosphoSitePlus | |
| T618 | SRTDDtAQVTS | HPRD | |
| T440 | RRVSStWTTTT | PhosphoSitePlus; phosphoELM | |
| S292 | KRRRRsSSVVS | PhosphoSitePlus | |
| S293 | RRRRSsSVVSA | PhosphoSitePlus | |
| T568 | RALTYtQSAPD | PhosphoSitePlus | |
| S428 | KRLRRsLPPGL | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y497 | SFTSSyAISAA | PhosphoSitePlus | |
| S520 | ALAKIsPLSSP | PhosphoSitePlus; HPRD; SysPTM | |
| Dephosphorylation site |
| PDE3A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000351957 | V607L | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000351957 | G1024R | COSMIC | Skin Cancer | 21984974 | ENSP00000351957 | A653P | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351957 | K508E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000351957 | C585F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351957 | S852T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000351957 | V285L | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000351957 | V349I | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000351957 | S852T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351957 | V928F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351957 | A653P | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| PDE3A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDE3A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT3_HUMAN | PDE3A_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04914 | Progesterone-mediated oocyte maturation |
| hsa05032 | Morphine addiction |
| hsa04910 | Insulin signaling pathway |
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase | IEA | molecular_function |
| GO:0006198 | cAMP catabolic process | IDA | biological_process |
| GO:0030552 | cAMP binding | IEA | molecular_function |
| GO:0019934 | cGMP-mediated signaling | IMP | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0043116 | negative regulation of vascular permeability | IMP | biological_process |
| GO:0040020 | regulation of meiosis | IEA | biological_process |
| GO:0001556 | oocyte maturation | IEA | biological_process |
| GO:0051591 | response to cAMP | IEA | biological_process |
| GO:0060282 | positive regulation of oocyte development | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0019933 | cAMP-mediated signaling | IMP | biological_process |
| GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0043117 | positive regulation of vascular permeability | IMP | biological_process |
| GO:0016101 | diterpenoid metabolic process | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0042493 | response to drug | IEA | biological_process |
| GO:0071321 | cellular response to cGMP | IDA | biological_process |
| GO:0071560 | cellular response to transforming growth factor be | IEP | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0006198 | cAMP catabolic process | IEA | biological_process |
| GO:0006629 | lipid metabolic process | TAS | biological_process |