| UniProt/SwissProt ID: | AKTS1_HUMAN |
| Description: | AKT1 substrate 1 (proline-rich) [Source:HGNC Symbol;Acc:28426] |
| Location: | chr19 q13.33 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S211 | ENGPPsSPDLD | Senescence_reg | PhosphoSitePlus |
| T198 | FKEKRtEARSS | Senescence_reg | PhosphoSitePlus |
| T246 | RPRLNtSDFQK | PKB_group | phosphoELM |
| S203 | TEARSsDEENG | HPRD; phosphoELM; RegPhos | |
| S116 | TETETsGEQLG | RegPhos | |
| T246 | RPRLNtSDFQK | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T246 | RPRLNtSDFQK | AKT1 | HPRD; RegPhos |
| T246 | RPRLNtSDFQK | AKT2 | HPRD; RegPhos |
| S202 | RTEARsSDEEN | HPRD; phosphoELM; RegPhos | |
| S183 | QQYAKsLPVSV | HPRD; phosphoELM; RegPhos; SysPTM | |
| T198 | FKEKRtEARSS | HPRD | |
| T73 | AHRAAtAARPP | PhosphoSitePlus; HPRD | |
| S183 | QQYAKsLPVSV | Senescence_reg | PhosphoSitePlus; SysPTM |
| T97 | SPPRPtLARED | PhosphoSitePlus; HPRD; phosphoELM | |
| S221 | DRIAAsMRALV | PhosphoSitePlus | |
| S88 | APQPPsPTPSP | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y256 | KLKRKy_____ | PhosphoSitePlus | |
| S202 | RTEARsSDEEN | Senescence_reg | PhosphoSitePlus |
| S212 | NGPPSsPDLDR | Senescence_reg | PhosphoSitePlus; SysPTM |
| T90 | QPPSPtPSPPR | PhosphoSitePlus; HPRD; phosphoELM | |
| S211 | ENGPPsSPDLD | HPRD; phosphoELM; RegPhos | |
| T32 | ELVLLtAAPPP | PhosphoSitePlus | |
| S92 | PSPTPsPPRPT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S203 | TEARSsDEENG | Senescence_reg | PhosphoSitePlus |
| T246 | RPRLNtSDFQK | AKT1(PKB) | RegPhos |
| S247 | PRLNTsDFQKL | PhosphoSitePlus | |
| S212 | NGPPSsPDLDR | HPRD; phosphoELM; RegPhos; SysPTM | |
| Dephosphorylation site |
| AKTS1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| AKTS1_HUMAN do not have mutation site. |
| Differential expressed protein |
| AKTS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| AKTS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT3_HUMAN | AKTS1_HUMAN | kinase -> substrate | KEGG |
| AKT2_HUMAN | AKTS1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | AKTS1_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | AKTS1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| AKTS1_HUMAN | MTOR_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04150 | mTOR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0045792 | negative regulation of cell size | IDA | biological_process |
| GO:0007173 | epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0032007 | negative regulation of TOR signaling cascade | IEA | biological_process |
| GO:0044445 | cytosolic part | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0048011 | nerve growth factor receptor signaling pathway | IEA | biological_process |
| GO:0006469 | negative regulation of protein kinase activity | IDA | biological_process |
| GO:0048015 | phosphatidylinositol-mediated signaling | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008543 | fibroblast growth factor receptor signaling pathwa | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031931 | TORC1 complex | IDA | cellular_component |
| GO:0043523 | regulation of neuron apoptotic process | IEA | biological_process |