| UniProt/SwissProt ID: | ZHX1_HUMAN |
| Description: | zinc fingers and homeoboxes 1 [Source:HGNC Symbol;Acc:12871] |
| Location: | chr8 q24.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T9 | RRKSTtPCMVL | PhosphoSitePlus; HPRD; phosphoELM | |
| S648 | EAGETsPADES | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T682 | SAFVRtQWPSP | HPRD; phosphoELM | |
| T782 | KFKTGtAILKD | Homez | PhosphoSitePlus |
| Y303 | LLLNTyNKFPY | HPRD; phosphoELM | |
| S202 | AVHHNsVEDVP | HPRD | |
| S635 | MEIDEsNAGSS | HPRD | |
| T36 | GPPVLtPVENT | PhosphoSitePlus; phosphoELM; SysPTM | |
| T780 | LIKFKtGTAIL | Homez | PhosphoSitePlus |
| T568 | PFPDFtPQKFK | PhosphoSitePlus | |
| S48 | AESISsDEEVH | PhosphoSitePlus; HPRD; phosphoELM | |
| S639 | ESNAGsSKEEA | PhosphoSitePlus; HPRD | |
| Y289 | NSIPTyNAALD | PhosphoSitePlus; HPRD; phosphoELM | |
| S47 | RAESIsSDEEV | PhosphoSitePlus; HPRD; phosphoELM | |
| S7 | TPCM | HPRD | |
| S26 | DLELIsDLDEG | HPRD; phosphoELM | |
| Y303 | LLLNTyNKFPY | Homeobox | PhosphoSitePlus |
| Y789 | ILKDYyLKHKF | Homez | PhosphoSitePlus |
| T682 | SAFVRtQWPSP | Homeobox | PhosphoSitePlus |
| S7 | ASRRKsTTPCM | PhosphoSitePlus | |
| S660 | APKSGsTGKIC | PhosphoSitePlus | |
| S640 | SNAGSsKEEAG | HPRD | |
| S45 | NTRAEsISSDE | PhosphoSitePlus; HPRD; phosphoELM | |
| T8 | SRRKStTPCMV | HPRD | |
| Dephosphorylation site |
| ZHX1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000378938 | R42T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000378938 | E326* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000297857 | R42T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000378938 | D843N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| ZHX1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ZHX1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TOPK_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM2_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK21_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK09_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CSK22_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAST1_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK03_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK10_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NTRK3_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PLK1_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3B_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PAK4_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK14_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDK1L_HUMAN | ZHX1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZHX1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0046982 | protein heterodimerization activity | IDA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IDA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0003714 | transcription corepressor activity | IDA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |