Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZHX1_HUMAN
Description:zinc fingers and homeoboxes 1 [Source:HGNC Symbol;Acc:12871]
Location:chr8 q24.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T9RRKSTtPCMVLPhosphoSitePlus; HPRD; phosphoELM
S648EAGETsPADESPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T682SAFVRtQWPSPHPRD; phosphoELM
T782KFKTGtAILKDHomezPhosphoSitePlus
Y303LLLNTyNKFPYHPRD; phosphoELM
S202AVHHNsVEDVPHPRD
S635MEIDEsNAGSSHPRD
T36GPPVLtPVENTPhosphoSitePlus; phosphoELM; SysPTM
T780LIKFKtGTAILHomezPhosphoSitePlus
T568PFPDFtPQKFKPhosphoSitePlus
S48AESISsDEEVHPhosphoSitePlus; HPRD; phosphoELM
S639ESNAGsSKEEAPhosphoSitePlus; HPRD
Y289NSIPTyNAALDPhosphoSitePlus; HPRD; phosphoELM
S47RAESIsSDEEVPhosphoSitePlus; HPRD; phosphoELM
S7TPCMHPRD
S26DLELIsDLDEGHPRD; phosphoELM
Y303LLLNTyNKFPYHomeoboxPhosphoSitePlus
Y789ILKDYyLKHKFHomezPhosphoSitePlus
T682SAFVRtQWPSPHomeoboxPhosphoSitePlus
S7ASRRKsTTPCMPhosphoSitePlus
S660APKSGsTGKICPhosphoSitePlus
S640SNAGSsKEEAGHPRD
S45NTRAEsISSDEPhosphoSitePlus; HPRD; phosphoELM
T8SRRKStTPCMVHPRD

Dephosphorylation site
ZHX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378938R42TBIOMARTBreast Cancer21930507, 21930502
ENSP00000378938E326*COSMICOvarian Cancer21720365
ENSP00000297857R42TBIOMARTBreast Cancer21930507, 21930502
ENSP00000378938D843NCOSMICHead and Neck Cancer21798893

Differential expressed protein
ZHX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ZHX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TOPK_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
KPCA_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PIM2_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CSK21_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MAST1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK10_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
NTRK3_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PAK4_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
MK08_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
PDK1L_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ZHX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process


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