Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TE2IP_HUMAN
Description:telomeric repeat binding factor 2, interacting protein [Source:HGNC Symbol;Acc:19246]
Location:chr16 q23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S154KENARsPSSVTHPRD; phosphoELM
T52LHGGGtVCRVQPhosphoSitePlus
S179QHSWQsLKDRYMyb_DNA-bind_2PhosphoSitePlus
T15DPNGPtHSSTLPhosphoSitePlus
T286DDDPPtPEEDSPhosphoSitePlus
T230PQNKRtPDLPEHPRD
S156NARSPsSVTGNHPRD; phosphoELM
S205APVSPsSQKLKPhosphoSitePlus; HPRD
Y195GQEHKyLLGDAHPRD
S156NARSPsSVTGNMyb_DNA-bind_2PhosphoSitePlus
T44KRRLStLILHGPhosphoSitePlus; HPRD; phosphoELM
S36FYVRPsPAKRRPhosphoSitePlus; HPRD; phosphoELM
S43AKRRLsTLILHPhosphoSitePlus
S203GDAPVsPSSQKPhosphoSitePlus; HPRD; phosphoELM
S154KENARsPSSVTMyb_DNA-bind_2PhosphoSitePlus
Y32SSMSFyVRPSPHPRD
S206PVSPSsQKLKRPhosphoSitePlus; HPRD; phosphoELM
S176SLTQHsWQSLKMyb_DNA-bind_2PhosphoSitePlus
S291TPEEDsETQPDPhosphoSitePlus

Dephosphorylation site
TE2IP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000300086A104VCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000300086Uterine CancerNormal vs. Cancercell lineUp1015838902

Hyperphosphorylation site
TE2IP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK3_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TE2IP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005654nucleoplasmTAScellular_component
GO:0005737cytoplasmISScellular_component
GO:0048239negative regulation of DNA recombination at telomeISSbiological_process
GO:0010833telomere maintenance via telomere lengtheningIEAbiological_process
GO:0007004telomere maintenance via telomeraseTASbiological_process
GO:0000783nuclear telomere cap complexIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0000784nuclear chromosome, telomeric regionIDAcellular_component
GO:0000723telomere maintenanceIDAbiological_process
GO:0000781chromosome, telomeric regionISScellular_component
GO:0000784nuclear chromosome, telomeric regionIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0070198protein localization to chromosome, telomeric regiIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010569regulation of double-strand break repair via homolISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0030870Mre11 complexIDAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cISSbiological_process
GO:0032205negative regulation of telomere maintenanceIMPbiological_process
GO:0031848protection from non-homologous end joining at teloIMPbiological_process
GO:0006355regulation of transcription, DNA-dependentISSbiological_process
GO:0000228nuclear chromosomeTAScellular_component
GO:0005634nucleusISScellular_component
GO:0000781chromosome, telomeric regionIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0010569regulation of double-strand break repair via homolIEAbiological_process
GO:0010833telomere maintenance via telomere lengtheningISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048239negative regulation of DNA recombination at telomeIEAbiological_process


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