Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TYK2_HUMAN
Description:tyrosine kinase 2 [Source:HGNC Symbol;Acc:12440]
Location:chr19 p13.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1054PEGHEyYRVREJAK1HPRD; phosphoELM; RegPhos
Y851SQCLTyEPTQRPkinase_TyrPhosphoSitePlus
Y433ADSSHyLCHEVPhosphoSitePlus
Y1054PEGHEyYRVREphosphoELM
Y1054PEGHEyYRVREautocatalysis RegPhos
S499PDGMQsLRLRKPhosphoSitePlus; HPRD; SysPTM
Y1055EGHEYyRVREDPkinase_TyrPhosphoSitePlus
Y423SLVDGyFRLTAPhosphoSitePlus
Y1055EGHEYyRVREDJAK1HPRD; phosphoELM; RegPhos
Y291AEGEPcYIRDSHPRD
S884TVNPDsPASDPPhosphoSitePlus; HPRD; SysPTM
Y1055EGHEYyRVREDTyk2phosphoELM; RegPhos
Y1054PEGHEyYRVREPkinase_TyrPhosphoSitePlus
Y1055EGHEYyRVREDphosphoELM
S577RTLNLsQLSFHPhosphoSitePlus
Y292EGEPCyIRDSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y827EKEHFyQRQHRPkinase_TyrPhosphoSitePlus
S339NKEEGsSGSSGPhosphoSitePlus
Y1145CPCEVyHLMKNPkinase_TyrPhosphoSitePlus
Y1054PEGHEyYRVRETyk2phosphoELM; RegPhos
S340KEEGSsGSSGRPhosphoSitePlus
Y604TRTNVyEGRLRRegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1054AVPEGHEyYRVREDGPTPRCHPRD
Y1055VPEGHEYyRVREDGDPTPRCHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264818H732RHPIColorectal Cancer17344846
ENSP00000264818L1109FCOSMICHead and Neck Cancer21984974
ENSP00000264818S394NCOSMICLung Cancer20668451
ENSP00000264818V298ECOSMICOvarian Cancer21720365
ENSP00000264818S1182LDing2008, COSMICLung Cancer18948947
ENSP00000431885C1187FCOSMICLung Cancer20668451
ENSP00000431885L1109FCOSMICHead and Neck Cancer21984974
ENSP00000264818C1187FCOSMICLung Cancer20668451
ENSP00000264818H732RGreenman2007, COSMICIntestines Cancer17344846, 18428421
ENSP00000264818A1069GDing2008, COSMICLung Cancer18948947
ENSP00000431885H732RCOSMICIntestines Cancer
ENSP00000264818R231QCOSMICLung Cancer20668451
ENSP00000431885V298ECOSMICOvarian Cancer21720365
ENSP00000431885M795VCOSMICOvarian Cancer20668451
ENSP00000431885R231QCOSMICLung Cancer20668451
ENSP00000431885S1182LCOSMICLung Cancer18948947
ENSP00000431885A1069GCOSMICLung Cancer18948947
ENSP00000264818M795VCOSMICOvarian Cancer20668451
ENSP00000431885S394NCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264818Uterine CancerNormal vs. CancertissueUp19007971

Hyperphosphorylation site
TYK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANTYK2_HUMANkinase -> substrateRegPhos
TYK2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANGBLP_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANNPM_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANNAR4_HUMANkinase -> substrateRobert H Newman (2013)
JAK1_HUMANTYK2_HUMANkinase -> substrateRegPhos
TYK2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANTYK2_HUMANkinase -> substrateNetPath
TYK2_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANINAR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TYK2_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANGCFC1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMAN1433E_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANTE2IP_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANI10R1_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
TYK2_HUMANSTAT1_HUMANkinase -> substrateHPRD; RegPhos
PTPRC_HUMANTYK2_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05164Influenza A
hsa04380Osteoclast differentiation
hsa05160Hepatitis C
hsa05162Measles
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0005131growth hormone receptor bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005856cytoskeletonIEAcellular_component


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