| UniProt/SwissProt ID: | IRF5_HUMAN |
| Description: | interferon regulatory factor 5 [Source:HGNC Symbol;Acc:6120] |
| Location: | chr7 q32.1 |
| Node attribute: | PPI(source); PPI(target); substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S293 | LFGPIsLEQVR | IRF-3 | PhosphoSitePlus |
| S158 | MLPSLsLTEDV | PhosphoSitePlus | |
| Y136 | QPPEDySFGAG | PhosphoSitePlus | |
| S440 | SWSADsIRLQI | PhosphoSitePlus | |
| S435 | FSGELsWSADS | PhosphoSitePlus | |
| T10 | IPVAPtPPRRV | PhosphoSitePlus | |
| S446 | IRLQIsNPDLK | PhosphoSitePlus | |
| S437 | GELSWsADSIR | PhosphoSitePlus | |
| S301 | QVRFPsPEDIP | IRF-3 | PhosphoSitePlus |
| Dephosphorylation site |
| IRF5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| IRF5_HUMAN do not have mutation site. |
| Differential expressed protein |
| IRF5_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IRF5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TBK1_HUMAN | IRF5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK16_HUMAN | IRF5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | IRF5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRAF6_HUMAN | IRF5_HUMAN | other | KEGG |
| IRF5_HUMAN | CCL5_HUMAN | other | KEGG |
| IRF5_HUMAN | CCL3_HUMAN | other | KEGG |
| IRF5_HUMAN | IL12A_HUMAN | other | KEGG |
| IRF5_HUMAN | IL6_HUMAN | other | KEGG |
| IRF5_HUMAN | IL8_HUMAN | other | KEGG |
| IRF5_HUMAN | IL1B_HUMAN | other | KEGG |
| IRF5_HUMAN | TNFA_HUMAN | TF -> target gene | KEGG |
| IRF5_HUMAN | IFNA1_HUMAN | TF -> target gene | TRANSFAC |
| IRF5_HUMAN | IFN14_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04620 | Toll-like receptor signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0043065 | positive regulation of apoptotic process | IMP | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | type I interferon-mediated signaling pathway | TAS | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0051607 | defense response to virus | IEA | biological_process |
| GO:0000975 | regulatory region DNA binding | IEA | molecular_function |
| GO:0032727 | positive regulation of interferon-alpha production | IC | biological_process |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0032494 | response to peptidoglycan | IDA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0032495 | response to muramyl dipeptide | IDA | biological_process |
| GO:0032735 | positive regulation of interleukin-12 production | IC | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0032728 | positive regulation of interferon-beta production | IC | biological_process |