| UniProt/SwissProt ID: | RUVB2_HUMAN |
| Description: | RuvB-like 2 (E. coli) [Source:HGNC Symbol;Acc:10475] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S26 | RIGAHsHIRGL | PhosphoSitePlus | |
| S220 | YDAMGsQTKFV | phosphoELM | |
| T81 | AGQPGtGKTAI | PhosphoSitePlus | |
| S110 | GSEIFsLEMSK | PhosphoSitePlus | |
| Y172 | EMETIyDLGTK | TIP49 | PhosphoSitePlus |
| S220 | YDAMGsQTKFV | TIP49 | PhosphoSitePlus |
| Y215 | TRARDyDAMGS | TIP49 | PhosphoSitePlus |
| T419 | RKRKGtEVQVD | TIP49 | PhosphoSitePlus |
| T222 | AMGSQtKFVQC | TIP49 | PhosphoSitePlus |
| S431 | IKRVYsLFLDE | TIP49 | PhosphoSitePlus |
| Y430 | DIKRVySLFLD | TIP49 | PhosphoSitePlus |
| Dephosphorylation site |
| RUVB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RUVB2_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000221413 | colorectal cancer | Normal vs. Cancer | tissue | Up | 1.6 | 19098285 |
| Hyperphosphorylation site |
| RUVB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK4_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K7_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FAK2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M4K2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK08_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FGFR2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6A4_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PIM1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK16_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PTK6_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCZ_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FRK_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TNI3K_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KKCC1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TBK1_HUMAN | RUVB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RUVB2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016363 | nuclear matrix | IEA | cellular_component |
| GO:0043967 | histone H4 acetylation | IDA | biological_process |
| GO:0035267 | NuA4 histone acetyltransferase complex | IDA | cellular_component |
| GO:0016887 | ATPase activity | IDA | molecular_function |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | IDA | biological_process |
| GO:0051082 | unfolded protein binding | TAS | molecular_function |
| GO:0003678 | DNA helicase activity | IDA | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0034644 | cellular response to UV | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0006457 | protein folding | TAS | biological_process |
| GO:0040008 | regulation of growth | IEA | biological_process |
| GO:0042802 | identical protein binding | IDA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006310 | DNA recombination | IEA | biological_process |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0031011 | Ino80 complex | IDA | cellular_component |
| GO:0043968 | histone H2A acetylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0032508 | DNA duplex unwinding | IDA | biological_process |