Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSA7_HUMAN
Description:proteasome (prosome, macropain) subunit, alpha type, 7 [Source:HGNC Symbol;Acc:9536]
Location:chr20 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S30AVKKGsTAVGVHPRD
S11AITVFsPDGHLProteasome_A_NPhosphoSitePlus
S201LEVVQsGGKNIHPRD
S201LEVVQsGGKNIProteasomePhosphoSitePlus
T108TVEYItRYIASHPRD
S11AITVFsPDGHLHPRD
T152TDPSGtYHAWKProteasomePhosphoSitePlus
Y153DPSGTyHAWKAProteasomePhosphoSitePlus
Y106PVTVEyITRYIHPRD
S167GRGAKsVREFLProteasomePhosphoSitePlus
S150YQTDPsGTYHAProteasomePhosphoSitePlus

Dephosphorylation site
PSA7_HUMAN do not have dephosphorylation site.

Mutation site
PSA7_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359910Lung CancerCancer vs. Cancercell lineDown17284061
ENSP00000359910Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000359910Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PSA7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK6_HUMANPSA7_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PSA7_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0000502proteasome complexTAScellular_component
GO:0051603proteolysis involved in cellular protein catabolicIEAbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0004298threonine-type endopeptidase activityIEAmolecular_function
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0019773proteasome core complex, alpha-subunit complexIEAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0005839proteasome core complexISScellular_component
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0016070RNA metabolic processTASbiological_process
GO:0005839proteasome core complexIEAcellular_component
GO:0010467gene expressionTASbiological_process


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