Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MFN1_HUMAN
Description:mitofusin 1 [Source:HGNC Symbol;Acc:18262]
Location:chr3 q26.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T687QQVDItQKQLEFzo_mitofusinPhosphoSitePlus

Dephosphorylation site
MFN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263969D415HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000263969E209KTCGAOvarian Cancer21720365, 18772890
ENSP00000420617E209KTCGAOvarian Cancer21720365, 18772890
ENSP00000263969D415HHPIColorectal Cancer16959974
ENSP00000420617F35YTCGAOvarian Cancer21720365, 18772890
ENSP00000420617D415HHPIColorectal Cancer16959974
ENSP00000263969L484PCOSMICOvarian Cancer21720365
ENSP00000263969F35YTCGAOvarian Cancer21720365, 18772890
ENSP00000263969F35YCOSMICOvarian Cancer21720365
ENSP00000263969E209KCOSMICOvarian Cancer21720365

Differential expressed protein
MFN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MFN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NEK6_HUMANMFN1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MFN1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003924GTPase activityIEAmolecular_function
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0016021integral to membraneNAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008053mitochondrial fusionIEAbiological_process
GO:0006184GTP catabolic processIEAbiological_process


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