Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDK2_HUMAN
Description:pyruvate dehydrogenase kinase, isozyme 2 [Source:HGNC Symbol;Acc:8810]
Location:chr17 q21.33
Node attribute:kinase; substrate

Phosphorylation site
PDK2_HUMAN do not have phosphorylation site.

Dephosphorylation site
PDK2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000420927E46KCOSMICSkin Cancer21984974
ENSP00000007708P118STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000420927G342RCOSMICCentral Nervous System Neoplasms16618716
ENSP00000420927P182SCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
PDK2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDK2_HUMANSGK1_HUMANkinase -> substrateRegPhos
NEK6_HUMANPDK2_HUMANkinase -> substrateRobert H Newman (2013)
PDK2_HUMANODPA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
PDK2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010906regulation of glucose metabolic processISSbiological_process
GO:0034614cellular response to reactive oxygen speciesIMPbiological_process
GO:0006006glucose metabolic processIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0031670cellular response to nutrientISSbiological_process
GO:0005967mitochondrial pyruvate dehydrogenase complexISScellular_component
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinasIDAmolecular_function
GO:0008286insulin receptor signaling pathwayISSbiological_process
GO:0006111regulation of gluconeogenesisISSbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004672protein kinase activityTASmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0005759mitochondrial matrixTAScellular_component
GO:0042593glucose homeostasisISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0072332intrinsic apoptotic signaling pathway by p53 classIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006090pyruvate metabolic processTASbiological_process
GO:0010510regulation of acetyl-CoA biosynthetic process fromISSbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006885regulation of pHISSbiological_process
GO:0010565regulation of cellular ketone metabolic processISSbiological_process


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