| UniProt/SwissProt ID: | NEK6_HUMAN |
| Description: | NIMA-related kinase 6 [Source:HGNC Symbol;Acc:7749] |
| Location: | chr9 q33.3 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T202 | FSSETtAAHSL | phosphoELM; RegPhos | |
| T69 | QRHPNtLSFRC | HPRD | |
| S158 | FVQLCsAVEHM | Pkinase | PhosphoSitePlus |
| Y212 | LVGTPyYMSPE | Pkinase | PhosphoSitePlus |
| T201 | FFSSEtTAAHS | Pkinase | PhosphoSitePlus |
| T35 | QRHPNtLSFRC | PhosphoSitePlus; HPRD | |
| S199 | GRFFSsETTAA | Pkinase | PhosphoSitePlus |
| S37 | HPNTLsFRCSL | PhosphoSitePlus | |
| T210 | HSLVGtPYYMS | Pkinase | PhosphoSitePlus |
| Y213 | VGTPYyMSPER | Pkinase | PhosphoSitePlus |
| S206 | TTAAHsLVGTP | Pkinase | PhosphoSitePlus |
| Y108 | PNIIKyLDSFI | Pkinase | PhosphoSitePlus |
| S165 | VEHMHsRRVMH | Pkinase | PhosphoSitePlus |
| S206 | TTAAHsLVGTP | NEK9 | HPRD; phosphoELM; RegPhos |
| S215 | TPYYMsPERIH | Pkinase | PhosphoSitePlus |
| T202 | FSSETtAAHSL | Pkinase | PhosphoSitePlus |
| Y152 | RTVWKyFVQLC | Pkinase | PhosphoSitePlus |
| Dephosphorylation site |
| NEK6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377749 | Y300C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000362702 | Y300C | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| NEK6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| NEK6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NEK6_HUMAN | SRA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | BPL1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | DCP1A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK9_HUMAN | NEK6_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| STK24_HUMAN | NEK6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | ZN346_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | PSA7_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | CIP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | GCFC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | PSA7L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | SGK1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| NEK6_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | PDK2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | FABP4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | KAT5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | SMC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | NEK6_HUMAN | kinase -> substrate | RegPhos |
| NEK6_HUMAN | MFN1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | RU17_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | NAA16_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | CSRP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | HSF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | RAB14_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| NEK6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0030071 | regulation of mitotic metaphase/anaphase transitio | IDA | biological_process |
| GO:0007059 | chromosome segregation | IDA | biological_process |
| GO:0007165 | signal transduction | IMP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0018105 | peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB c | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0000287 | magnesium ion binding | IDA | molecular_function |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0051225 | spindle assembly | TAS | biological_process |
| GO:0031572 | G2/M transition DNA damage checkpoint | IMP | biological_process |
| GO:0000910 | cytokinesis | TAS | biological_process |
| GO:2000772 | regulation of cellular senescence | TAS | biological_process |
| GO:0046777 | protein autophosphorylation | IDA | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007346 | regulation of mitotic cell cycle | TAS | biological_process |
| GO:0005815 | microtubule organizing center | IEA | cellular_component |
| GO:0004871 | signal transducer activity | IMP | molecular_function |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0019894 | kinesin binding | IPI | molecular_function |