Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DAPK1_HUMAN
Description:death-associated protein kinase 1 [Source:HGNC Symbol;Acc:2674]
Location:chr9 q21.33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S606CNLDIsNKYGRAnk_2PhosphoSitePlus
S736SRFPPsPLASKMAPK1phosphoELM
S308KKWKQsVRLISDAPK_groupphosphoELM; RegPhos
S308KKWKQsVRLISDAPK1HPRD; phosphoELM; RegPhos
S725RPRLSsTNSSRAAA_16PhosphoSitePlus
Y39STGLQyAAKFIPkinasePhosphoSitePlus
S289LSRKAsAVNMEPhosphoSitePlus
S308KKWKQsVRLISPhosphoSitePlus
S724RRPRLsSTNSSAAA_16PhosphoSitePlus
S289LSRKAsAVNMERSK-2phosphoELM
S308KKWKQsVRLISautocatalysisRegPhos
Y1060RALHHyRGRYTPhosphoSitePlus
S736SRFPPsPLASKErk2(MAPK1RegPhos
Y490AAWHGyYSVAKAnk_2PhosphoSitePlus
S289LSRKAsAVNMERSK_groupphosphoELM; RegPhos
Y491AWHGYySVAKAAnk_2PhosphoSitePlus
S326SFLSRsNMSVAPhosphoSitePlus
S57SRRGVsREDIEPkinasePhosphoSitePlus
S333MSVARsDDTLDAnk_2PhosphoSitePlus
S734SRFPPsPLASKAAA_16PhosphoSitePlus
S728LSSTNsSRFPPAAA_16PhosphoSitePlus
S736SRFPPsPLASKErk2RegPhos
T1269KETSLtNTMGGPhosphoSitePlus
S734SRFPPsPLASKMAPK1HPRD
Y13NVDDYyDTGEEPkinasePhosphoSitePlus
S1267TLKETsLTNTMPhosphoSitePlus
S289LSRKAsAVNMERSK2RegPhos
Y12ENVDDyYDTGEPhosphoSitePlus
T1266QTLKEtSLTNTPhosphoSitePlus

Dephosphorylation site
DAPK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386135P982SCOSMICHead and Neck Cancer21798893
ENSP00000386135R730KCOSMICSkin Cancer21984974
ENSP00000350785I1156FBIOMARTBreast Cancer21930507, 21930502
ENSP00000386135L1330FCOSMICHead and Neck Cancer21798893
ENSP00000386135I1156FBIOMARTBreast Cancer21930507, 21930502
ENSP00000386135E1182KCOSMICHead and Neck Cancer21798893
ENSP00000386135P1141SCOSMICSkin Cancer21984974
ENSP00000417076I1156FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
DAPK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DAPK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANDAPK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6A3_HUMANDAPK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
DAPK1_HUMANSTX1A_HUMANkinase -> substrateHPRD; RegPhos
DAPK1_HUMANDAPK1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05219Bladder cancer
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:2000310regulation of N-methyl-D-aspartate selective glutaISSbiological_process
GO:0071346cellular response to interferon-gammaIDAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005516calmodulin bindingIEAmolecular_function
GO:0097190apoptotic signaling pathwayIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0015629actin cytoskeletonIDAcellular_component
GO:0006917induction of apoptosisIMPbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0005516calmodulin bindingIDAmolecular_function
GO:0003824catalytic activityIEAmolecular_function
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0017148negative regulation of translationIDAbiological_process
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:2000310regulation of N-methyl-D-aspartate selective glutaIEAbiological_process
GO:0046777protein autophosphorylationTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0006915apoptotic processIGIbiological_process
GO:0042981regulation of apoptotic processTASbiological_process
GO:0010506regulation of autophagyTASbiological_process


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