Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TNR16_HUMAN
Description:nerve growth factor receptor [Source:HGNC Symbol;Acc:7809]
Location:chr17 q21.33
Node attribute:receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S303GEKLHsDSGISPRKACBHPRD
S313SVDSQsLHDQQPhosphoSitePlus; HPRD
Y336GDGGLySSLPPPhosphoSitePlus
S303GEKLHsDSGISPhosphoSitePlus
S303GEKLHsDSGISPKACbRegPhos
S277FKRWNsCKQNKDUF2133PhosphoSitePlus
S303GEKLHsDSGISPKA_groupphosphoELM; RegPhos

Dephosphorylation site
TNR16_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000172229G334DCOSMICHepatocellular Carcinoma21822264
ENSP00000172229A355SCOSMICOvarian Cancer21720365
ENSP00000172229A355STCGAOvarian Cancer21720365, 18772890
ENSP00000172229C32*COSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000172229Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
TNR16_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NGF_HUMANTNR16_HUMANligand -> receptorHPMR
KAPCB_HUMANTNR16_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneIEAcellular_component
GO:0050771negative regulation of axonogenesisTASbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0050770regulation of axonogenesisTASbiological_process
GO:0050772positive regulation of axonogenesisTASbiological_process
GO:0017137Rab GTPase bindingISSmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0042488positive regulation of odontogenesis of dentin-conIEAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0042593glucose homeostasisISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0051799negative regulation of hair follicle developmentIEAbiological_process
GO:0006886intracellular protein transportISSbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0009986cell surfaceISScellular_component
GO:0007411axon guidanceIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIEAbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0016048detection of temperature stimulusIEAbiological_process
GO:0045786negative regulation of cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005768endosomeTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0048406nerve growth factor bindingIEAmolecular_function
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0010468regulation of gene expressionIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0005035death receptor activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0021675nerve developmentIEAbiological_process
GO:0004872receptor activityTASmolecular_function
GO:2001273regulation of glucose import in response to insuliISSbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0040037negative regulation of fibroblast growth factor reIEAbiological_process


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