Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FGFR2_HUMAN
Description:fibroblast growth factor receptor 2 [Source:HGNC Symbol;Acc:3689]
Location:chr10 q26.13
Node attribute:receptor; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y769TTNEEyLDLSQPhosphoSitePlus; HPRD; phosphoELM
S453TTRLSsTADTPPhosphoSitePlus
S791TRSSCsSGDDSPhosphoSitePlus
S347CLAGNsIGISFI-setPhosphoSitePlus
T448PLVRItTRLSSPhosphoSitePlus
S788YPDTRsSCSSGPhosphoSitePlus
T454TRLSStADTPMPhosphoSitePlus
Y780QPLEQySPSYPHPRD
Y770TTNEEyLDLSQHPRD
Y586PPGMEySYDINPkinase_TyrPhosphoSitePlus
S533LSDLVsEMEMMPkinase_TyrPhosphoSitePlus
Y784QYSPSyPDTRSHPRD
Y812PCLPQyPHINGPhosphoSitePlus; HPRD
Y733CTNELyMMMRDPkinase_TyrPhosphoSitePlus
T442SMNSNtPLVRIPhosphoSitePlus
S437AESSSsMNSNTPhosphoSitePlus
Y813PCLPQyPHINGHPRD
S789PDTRSsCSSGDPhosphoSitePlus
S792RSSCSsGDDSVPhosphoSitePlus
Y657NNIDYyKKTTNPkinase_TyrPhosphoSitePlus
Y616ARGMEyLASQKPkinase_TyrPhosphoSitePlus
Y656INNIDyYKKTTPkinase_TyrPhosphoSitePlus
S782EQYSPsYPDTRPhosphoSitePlus
T457SSTADtPMLAGPhosphoSitePlus
S452ITTRLsSTADTPhosphoSitePlus
T449LVRITtRLSSTPhosphoSitePlus
S587PGMEYsYDINRPkinase_TyrPhosphoSitePlus
S440SSSMNsNTPLVPhosphoSitePlus
Y805PDPMPyEPCLPPhosphoSitePlus
Y783QYSPSyPDTRSHPRD
Y466AGVSEyELPEDPhosphoSitePlus
Y608LVSCTyQLARGPkinase_TyrPhosphoSitePlus
Y779QPLEQySPSYPHPRD
Y588GMEYSyDINRVPkinase_TyrPhosphoSitePlus

Dephosphorylation site
FGFR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351276A314DCOSMICUterine Cancer18552176
ENSP00000351276D283NHPI, COSMICLung Cancer17344846, 16140923
ENSP00000351276G305RCOSMICMelanoma19147536
ENSP00000351276R251QCOSMICMelanoma19147536
ENSP00000351276Y375COMIMUterine Cancer17525745
ENSP00000351276E475KCOSMICMelanoma19147536
ENSP00000351276I642VCOSMICMelanoma19147536
ENSP00000351276E219KCOSMICMelanoma19147536
ENSP00000351276L770VCOSMICMelanoma19147536
ENSP00000351276I547VCOSMICUterine Cancer17525745
ENSP00000351276V248DCOSMICMelanoma19147536
ENSP00000351276I380VCOSMICLung Cancer18948947
ENSP00000351276D530NCOSMICMelanoma19147536
ENSP00000351276R203CHPI, COSMICBreast Cancer16959974 17344846 19900242 19048480, 15908952
ENSP00000351276T370RCOSMICMelanoma19147536
ENSP00000351276W290CCOSMICLung Cancer16140923
ENSP00000351276G271ECOSMICMelanoma19147536
ENSP00000351276S267POMIM, COSMICGastric Cancer10394936 11325814
ENSP00000351276P303LCOSMICSkin Cancer19812598
ENSP00000351276S688FCOSMICMelanoma19147536
ENSP00000351276A389TCOSMICUterine Cancer18552176
ENSP00000351276R612THPI, COSMICLung Cancer17344846, 16140923
ENSP00000410294R203CBIOMARTBreast Cancer21930507, 21930502
ENSP00000351276S252WOMIMUterine Cancer17525745
ENSP00000351276L560FCOSMICLung Cancer20668451
ENSP00000351276R759QCOSMICMelanoma19147536
ENSP00000351276P253RCOSMICUterine Cancer18552176
ENSP00000351276V77MCOSMICMelanoma19147536
ENSP00000351276K310RCOSMICUterine Cancer18552176
ENSP00000351276H213YCOSMICMelanoma19147536
ENSP00000351276H544QCOSMICLung Cancer18948947
ENSP00000351276N211ICOSMICLung Cancer18552176
ENSP00000351276A97TCOSMICUterine Cancer18552176
ENSP00000351276M640ICOSMICMelanoma19147536
ENSP00000351276G272VHPI, COSMICOvarian Cancer17344846
ENSP00000351276Q212KCOSMICCentral Nervous System Neoplasms18772890
ENSP00000351276E636KCOSMICMelanoma19147536
ENSP00000351276W474*COSMICMelanoma19147536
ENSP00000351276P708SCOSMICMelanoma19147536
ENSP00000351276S24FCOSMICMelanoma19147536
ENSP00000351276M391RCOSMICUterine Cancer17525745
ENSP00000351276G613VCOSMICLung Cancer20668451
ENSP00000351276N549KCOSMICUterine Cancer18552176
ENSP00000351276C382RCOSMICUterine Cancer18552176
ENSP00000351276S252WCOSMICUterine Cancer18552176
ENSP00000351276V392ACOSMICHead and Neck Cancer21798897
ENSP00000351276K659NCOSMICUterine Cancer18552176
ENSP00000351276D101YCOSMICUterine Cancer18552176
ENSP00000351276Y375CCOSMICOvarian Cancer20106510
ENSP00000351276A315TCOSMICUterine Cancer17525745
ENSP00000351276E465*COSMICLung Cancer20668451
ENSP00000351276A648TCOSMICMelanoma19147536
ENSP00000351276S372CCOSMICUterine Cancer17525745
ENSP00000351276G227ECOSMICMelanoma19147536
ENSP00000351276E160ACOSMICMelanoma19147536
ENSP00000351276E574KCOSMICMelanoma19147536

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358057Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
FGFR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGF7_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF10_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF22_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF4_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF3_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF2_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF9_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF23_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF5_HUMANFGFR2_HUMANligand -> receptorHPMR
FGF8_HUMANFGFR2_HUMANligand -> receptorHPMR
FGFR2_HUMANMRF_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANM18BP_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANZN784_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANLUZP1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCBL_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANNUDT4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANZN765_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANKCC1B_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANKHDR1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANTOX_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANKPYM_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCENPS_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANTFE2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANZN397_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCP250_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANSMAD4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANLARP6_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCRK_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANOAS1_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04144Endocytosis
hsa05200Pathways in cancer
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway
hsa05215Prostate cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030855epithelial cell differentiationISSbiological_process
GO:0008589regulation of smoothened signaling pathwayISSbiological_process
GO:0060463lung lobe morphogenesisISSbiological_process
GO:0051150regulation of smooth muscle cell differentiationIEAbiological_process
GO:0060523prostate epithelial cord elongationIEAbiological_process
GO:0060595fibroblast growth factor receptor signaling pathwaISSbiological_process
GO:0003149membranous septum morphogenesisISSbiological_process
GO:0060449bud elongation involved in lung branchingISSbiological_process
GO:0048608reproductive structure developmentISSbiological_process
GO:0060601lateral sprouting from an epitheliumISSbiological_process
GO:0060529squamous basal epithelial stem cell differentiatioIEAbiological_process
GO:0060667branch elongation involved in salivary gland morphISSbiological_process
GO:0045787positive regulation of cell cycleISSbiological_process
GO:0060670branching involved in labyrinthine layer morphogenISSbiological_process
GO:0030855epithelial cell differentiationIEAbiological_process
GO:0060045positive regulation of cardiac muscle cell prolifeIEAbiological_process
GO:0030282bone mineralizationISSbiological_process
GO:0003148outflow tract septum morphogenesisISSbiological_process
GO:0060687regulation of branching involved in prostate glandIEAbiological_process
GO:0001657ureteric bud developmentISSbiological_process
GO:0031069hair follicle morphogenesisISSbiological_process
GO:0045839negative regulation of mitosisIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0030916otic vesicle formationISSbiological_process
GO:0060601lateral sprouting from an epitheliumIEAbiological_process
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0060076excitatory synapseISScellular_component
GO:0022612gland morphogenesisIEAbiological_process
GO:0035602fibroblast growth factor receptor signaling pathwaISSbiological_process
GO:0048286lung alveolus developmentISSbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005938cell cortexIDAcellular_component
GO:0031012extracellular matrixIDAcellular_component
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0042476odontogenesisIEAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0060463lung lobe morphogenesisIEAbiological_process
GO:0030901midbrain developmentISSbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0035607fibroblast growth factor receptor signaling pathwaISSbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0007528neuromuscular junction developmentIEAbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0060523prostate epithelial cord elongationISSbiological_process
GO:0061031endodermal digestive tract morphogenesisIEAbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0032808lacrimal gland developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0051150regulation of smooth muscle cell differentiationISSbiological_process
GO:0030916otic vesicle formationIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0060045positive regulation of cardiac muscle cell prolifeISSbiological_process
GO:0060916mesenchymal cell proliferation involved in lung deISSbiological_process
GO:0060664epithelial cell proliferation involved in salivaryISSbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0060527prostate epithelial cord arborization involved in IEAbiological_process
GO:0048565digestive tract developmentISSbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0048568embryonic organ developmentISSbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0060527prostate epithelial cord arborization involved in ISSbiological_process
GO:0048562embryonic organ morphogenesisISSbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0007267cell-cell signalingIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0007409axonogenesisISSbiological_process
GO:0035265organ growthIEAbiological_process
GO:0048565digestive tract developmentIEAbiological_process
GO:0060484lung-associated mesenchyme developmentISSbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0030901midbrain developmentIEAbiological_process
GO:0033688regulation of osteoblast proliferationTASbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0060348bone developmentISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0090263positive regulation of canonical Wnt receptor signISSbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0048755branching morphogenesis of a nerveISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0060512prostate gland morphogenesisISSbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathISSbiological_process
GO:0010453regulation of cell fate commitmentIEAbiological_process
GO:0022612gland morphogenesisISSbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0008589regulation of smoothened signaling pathwayIEAbiological_process
GO:0060667branch elongation involved in salivary gland morphIEAbiological_process
GO:0017134fibroblast growth factor bindingIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaIPIbiological_process
GO:0060445branching involved in salivary gland morphogenesisISSbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0035265organ growthISSbiological_process
GO:0009791post-embryonic developmentISSbiological_process
GO:0048608reproductive structure developmentIEAbiological_process
GO:0009887organ morphogenesisISSbiological_process
GO:0035603fibroblast growth factor receptor signaling pathwaISSbiological_process
GO:0048489synaptic vesicle transportIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0021847ventricular zone neuroblast divisionISSbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0048755branching morphogenesis of a nerveIEAbiological_process
GO:0048762mesenchymal cell differentiationIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0060615mammary gland bud formationISSbiological_process
GO:0050679positive regulation of epithelial cell proliferatiISSbiological_process
GO:0060916mesenchymal cell proliferation involved in lung deIEAbiological_process
GO:0060174limb bud formationISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0002053positive regulation of mesenchymal cell proliferatISSbiological_process
GO:0016020membraneNAScellular_component
GO:0021769orbitofrontal cortex developmentISSbiological_process
GO:0048568embryonic organ developmentIEAbiological_process
GO:0060688regulation of morphogenesis of a branching structuISSbiological_process
GO:0050678regulation of epithelial cell proliferationIEAbiological_process
GO:0009880embryonic pattern specificationISSbiological_process
GO:0060349bone morphogenesisISSbiological_process
GO:0035264multicellular organism growthISSbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0048705skeletal system morphogenesisTASbiological_process
GO:0035604fibroblast growth factor receptor signaling pathwaISSbiological_process
GO:0040036regulation of fibroblast growth factor receptor siIEAbiological_process
GO:0005007fibroblast growth factor-activated receptor activiIGImolecular_function
GO:0060174limb bud formationIEAbiological_process
GO:0048562embryonic organ morphogenesisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0009887organ morphogenesisIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0007267cell-cell signalingISSbiological_process
GO:0045667regulation of osteoblast differentiationTASbiological_process
GO:0060349bone morphogenesisIEAbiological_process
GO:0001525angiogenesisISSbiological_process
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048557embryonic digestive tract morphogenesisISSbiological_process
GO:0060615mammary gland bud formationIEAbiological_process
GO:0042472inner ear morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0060449bud elongation involved in lung branchingIEAbiological_process
GO:0016331morphogenesis of embryonic epitheliumISSbiological_process
GO:0060365coronal suture morphogenesisIEAbiological_process
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0060501positive regulation of epithelial cell proliferatiISSbiological_process
GO:0060484lung-associated mesenchyme developmentIEAbiological_process
GO:0003149membranous septum morphogenesisIEAbiological_process
GO:0060915mesenchymal cell differentiation involved in lung IEAbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0048730epidermis morphogenesisIEAbiological_process
GO:0060670branching involved in labyrinthine layer morphogenIEAbiological_process
GO:0017134fibroblast growth factor bindingIPImolecular_function
GO:0003148outflow tract septum morphogenesisIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0060348bone developmentIEAbiological_process
GO:0032808lacrimal gland developmentISSbiological_process
GO:0016331morphogenesis of embryonic epitheliumIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0070307lens fiber cell developmentIEAbiological_process
GO:0060442branching involved in prostate gland morphogenesisIEAbiological_process
GO:0010453regulation of cell fate commitmentISSbiological_process
GO:0060595fibroblast growth factor receptor signaling pathwaIEAbiological_process
GO:0050673epithelial cell proliferationIEAbiological_process
GO:0060664epithelial cell proliferation involved in salivaryIEAbiological_process
GO:0010518positive regulation of phospholipase activityIMPbiological_process
GO:0060688regulation of morphogenesis of a branching structuIEAbiological_process
GO:0042472inner ear morphogenesisISSbiological_process
GO:0030324lung developmentISSbiological_process
GO:0060501positive regulation of epithelial cell proliferatiIEAbiological_process
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0040036regulation of fibroblast growth factor receptor siISSbiological_process
GO:0048730epidermis morphogenesisISSbiological_process
GO:0060529squamous basal epithelial stem cell differentiatioISSbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0021860pyramidal neuron developmentISSbiological_process
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0001701in utero embryonic developmentISSbiological_process
GO:0060915mesenchymal cell differentiation involved in lung ISSbiological_process
GO:0004713protein tyrosine kinase activityNASmolecular_function
GO:0060442branching involved in prostate gland morphogenesisISSbiological_process
GO:0060687regulation of branching involved in prostate glandISSbiological_process
GO:0030177positive regulation of Wnt receptor signaling pathIEAbiological_process
GO:0048762mesenchymal cell differentiationISSbiological_process
GO:0030282bone mineralizationIEAbiological_process
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0051781positive regulation of cell divisionISSbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0042476odontogenesisISSbiological_process
GO:0060512prostate gland morphogenesisIEAbiological_process
GO:0045165cell fate commitmentISSbiological_process