Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:OAS1_HUMAN
Description:2'-5'-oligoadenylate synthetase 1, 40/46kDa [Source:HGNC Symbol;Acc:8086]
Location:chr12 q24.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y271QQLCIyWTKYYOAS1_CPhosphoSitePlus
Y362DDPRRyQKYGYPhosphoSitePlus

Dephosphorylation site
OAS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000388001E175KTCGAOvarian Cancer21720365, 18772890
ENSP00000388001V262LTCGAOvarian Cancer21720365, 18772890
ENSP00000415721S352FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
OAS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
OAS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FGFR2_HUMANOAS1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
OAS1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingIDAmolecular_function
GO:0016779nucleotidyltransferase activityIEAmolecular_function
GO:0035457cellular response to interferon-alphaIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:00017302'-5'-oligoadenylate synthetase activityIDAmolecular_function
GO:0005739mitochondrionIEAcellular_component
GO:0060700regulation of ribonuclease activityIDAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0009615response to virusIDAbiological_process
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0051259protein oligomerizationIDAbiological_process
GO:0006164purine nucleotide biosynthetic processIDAbiological_process
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0016740transferase activityIEAmolecular_function
GO:0006955immune responseIEAbiological_process
GO:0005524ATP bindingTASmolecular_function
GO:0045071negative regulation of viral genome replicationIDAbiological_process
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0003725double-stranded RNA bindingIDAmolecular_function
GO:0051607defense response to virusIEAbiological_process


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