Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAT1_HUMAN
Description:menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis) [Source:HGNC Symbol;Acc:7181]
Location:chr14 q23.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T51CPECGtPLRKSPhosphoSitePlus; HPRD
S279HVRAAsPQDLAPhosphoSitePlus; HPRD
T225PVTFStGIKMGHPRD
S205QHKDRsTQLEMHPRD
T225PVTFStGIKMGMAT1PhosphoSitePlus
T222PVKPVtFSTGIMAT1PhosphoSitePlus
S205QHKDRsTQLEMMAT1PhosphoSitePlus
Y14CKTTKyRNPSLPhosphoSitePlus

Dephosphorylation site
MAT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261245P217SCOSMICHead and Neck Cancer21984974
ENSP00000261245L115FCOSMICHead and Neck Cancer21798893
ENSP00000261245*310SCOSMICOvarian Cancer21720365
ENSP00000261245S56GCOSMICLung Cancer20668451
ENSP00000261245L171VCOSMICOvarian Cancer21720365

Differential expressed protein
MAT1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MAT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAT1_HUMANESR1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03420Nucleotide excision repair
hsa03022Basal transcription factors

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0044236multicellular organismal metabolic processIEAbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0006361transcription initiation from RNA polymerase I proTASbiological_process
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0000082G1/S transition of mitotic cell cycleIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0006366transcription from RNA polymerase II promoterIDAbiological_process
GO:0000079regulation of cyclin-dependent protein kinase actiTASbiological_process
GO:0007512adult heart developmentIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008094DNA-dependent ATPase activityIDAmolecular_function
GO:0007049cell cycleIEAbiological_process
GO:0051592response to calcium ionIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008353RNA polymerase II carboxy-terminal domain kinase aIDAmolecular_function
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0006362transcription elongation from RNA polymerase I proTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0006281DNA repairTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0050790regulation of catalytic activityIEAbiological_process
GO:0005675holo TFIIH complexIDAcellular_component
GO:0000718nucleotide-excision repair, DNA damage removalTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0021591ventricular system developmentIEAbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function