Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NHRF1_HUMAN
Description:solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 [Source:HGNC Symbol;Acc:11075]
Location:chr17 q25.1
Node attribute:substrate; effector; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S191SPAEAsGLRAQPDZPhosphoSitePlus
S288PALVRsASSDTPhosphoSitePlus; HPRD
S316PSSTSsSDPILphosphoELM
S290LVRSAsSDTSEPhosphoSitePlus; HPRD; phosphoELM
S290LVRSAsSDTSEGRK-6phosphoELM
S2DAAAHPRD
S313STAPSsTSSSDPhosphoSitePlus
S339AHQKRsSKRAPEBP50_C-termPhosphoSitePlus
S46LVEPGsPAEKAPDZPhosphoSitePlus
Y38GKLGQyIRLVEPDZPhosphoSitePlus
S217HGDVVsAIRAGPDZPhosphoSitePlus
S2____MsADAAAPhosphoSitePlus
S46LVEPGsPAEKAHPRD
S77HQQVVsRIRAAPDZ; DUF1537PhosphoSitePlus
S290LVRSAsSDTSEGRK6HPRD
S326LDFNIsLAMAKHPRD
S299SEELNsQDSPPPhosphoSitePlus; HPRD
T293SASSDtSEELNPhosphoSitePlus; HPRD; phosphoELM
S170GFNLHsDKSKPPDZPhosphoSitePlus
S317SSTSSsDPILDHPRD
S294ASSDTsEELNSPhosphoSitePlus; HPRD
T156RPRLCtMKKGPPDZPhosphoSitePlus
S162MKKGPsGYGFNPKC_alphaphosphoELM
S302LNSQDsPPKQDPhosphoSitePlus; HPRD
S340HQKRSsKRAPQEBP50_C-termPhosphoSitePlus
S162MKKGPsGYGFNPDZPhosphoSitePlus
S269IQKENsREALAPhosphoSitePlus; HPRD; phosphoELM
Y164KGPSGyGFNLHPDZPhosphoSitePlus
T95VVDPEtDEQLQDUF1537PhosphoSitePlus
S280EAALEsPRPALPhosphoSitePlus; HPRD; phosphoELM
S291VRSASsDTSEEPhosphoSitePlus; HPRD; phosphoELM
S173LHSDKsKPGQFPDZPhosphoSitePlus

Dephosphorylation site
NHRF1_HUMAN do not have dephosphorylation site.

Mutation site
NHRF1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262613Hepatocellular CarcinomaNormal vs. Cancercell lineUp6.318646787
ENSP00000262613Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.618491314
ENSP00000262613Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4119329653
ENSP00000262613Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
NHRF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANNHRF1_HUMANGprotein -> effectorgpDB
ZAGL2_HUMANNHRF1_HUMANkinase -> substrateRegPhos
GRK6_HUMANNHRF1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KPCA_HUMANNHRF1_HUMANkinase -> substrateRobert H Newman (2013)
ESR1_HUMANNHRF1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
NHRF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0032782bile acid secretionIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0017081chloride channel regulator activityIDAmolecular_function
GO:0006915apoptotic processIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0016324apical plasma membraneIEAcellular_component
GO:0034635glutathione transportIEAbiological_process
GO:0031528microvillus membraneIEAcellular_component
GO:0045177apical part of cellIEAcellular_component
GO:0071944cell peripheryIDAcellular_component
GO:0005902microvillusIDAcellular_component
GO:0044062regulation of excretionIEAbiological_process
GO:0051898negative regulation of protein kinase B signaling IEAbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0015629actin cytoskeletonTAScellular_component
GO:0031698beta-2 adrenergic receptor bindingIPImolecular_function
GO:0030643cellular phosphate ion homeostasisIEAbiological_process
GO:0032415regulation of sodium:hydrogen antiporter activityNASbiological_process
GO:0043621protein self-associationIDAmolecular_function
GO:0007191adenylate cyclase-activating dopamine receptor sigIEAbiological_process
GO:0050780dopamine receptor bindingIEAmolecular_function
GO:0010642negative regulation of platelet-derived growth facIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0001726ruffleIEAcellular_component
GO:0003096renal sodium ion transportIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045859regulation of protein kinase activityIEAbiological_process
GO:0006461protein complex assemblyTASbiological_process
GO:0030033microvillus assemblyIMPbiological_process
GO:0030175filopodiumIEAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0014067negative regulation of phosphatidylinositol 3-kinaIEAbiological_process
GO:0097291renal phosphate ion absorptionIMPbiological_process
GO:0070293renal absorptionIEAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0060158phospholipase C-activating dopamine receptor signaIEAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0031526brush border membraneIEAcellular_component
GO:0019902phosphatase bindingIEAmolecular_function
GO:0034613cellular protein localizationIEAbiological_process
GO:0032416negative regulation of sodium:hydrogen antiporter IEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0010766negative regulation of sodium ion transportIEAbiological_process
GO:0070851growth factor receptor bindingIPImolecular_function
GO:0016020membraneIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component


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