Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:POLK_HUMAN
Description:polymerase (DNA directed) kappa [Source:HGNC Symbol;Acc:9183]
Location:chr5 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T44IIMEAtKGSRFPhosphoSitePlus
S831RSTGSsSGVQKPhosphoSitePlus
T372ALGIItCTELYHPRD; SysPTM
S830SRSTGsSSGVQPhosphoSitePlus
T839VQKAVtRTKRPPhosphoSitePlus
S827KESSRsTGSSSHPRD; SysPTM
Y686CEKQDyEAHPKPhosphoSitePlus
T372ALGIItCTELYIMSPhosphoSitePlus; SysPTM
S528KHQQRsIIGFLPhosphoSitePlus
S824NQPKEsSRSTGPhosphoSitePlus
S592AVNKQsFQTSQPhosphoSitePlus
S541GNQALsATECTPhosphoSitePlus
S479VSSVVsTAEEIIMSPhosphoSitePlus
S679NVPASsLCEKQPhosphoSitePlus
S825QPKESsRSTGSPhosphoSitePlus
T828ESSRStGSSSGPhosphoSitePlus
T848RPGLMtKYSTSPhosphoSitePlus

Dephosphorylation site
POLK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000241436R48ICOSMICOvarian Cancer21720365
ENSP00000241436F286SCOSMICRenal Cancer20054297
ENSP00000241436R48ITCGAOvarian Cancer21720365, 18772890
ENSP00000241436M364LCOSMICRenal Cancer20054297

Differential expressed protein
POLK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
POLK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TESK2_HUMANPOLK_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANPOLK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
POLK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0006281DNA repairIEAbiological_process
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0006297nucleotide-excision repair, DNA gap fillingIMPbiological_process
GO:0003887DNA-directed DNA polymerase activityIEAmolecular_function


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