| UniProt/SwissProt ID: | POLK_HUMAN |
| Description: | polymerase (DNA directed) kappa [Source:HGNC Symbol;Acc:9183] |
| Location: | chr5 q13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T44 | IIMEAtKGSRF | PhosphoSitePlus | |
| S831 | RSTGSsSGVQK | PhosphoSitePlus | |
| T372 | ALGIItCTELY | HPRD; SysPTM | |
| S830 | SRSTGsSSGVQ | PhosphoSitePlus | |
| T839 | VQKAVtRTKRP | PhosphoSitePlus | |
| S827 | KESSRsTGSSS | HPRD; SysPTM | |
| Y686 | CEKQDyEAHPK | PhosphoSitePlus | |
| T372 | ALGIItCTELY | IMS | PhosphoSitePlus; SysPTM |
| S528 | KHQQRsIIGFL | PhosphoSitePlus | |
| S824 | NQPKEsSRSTG | PhosphoSitePlus | |
| S592 | AVNKQsFQTSQ | PhosphoSitePlus | |
| S541 | GNQALsATECT | PhosphoSitePlus | |
| S479 | VSSVVsTAEEI | IMS | PhosphoSitePlus |
| S679 | NVPASsLCEKQ | PhosphoSitePlus | |
| S825 | QPKESsRSTGS | PhosphoSitePlus | |
| T828 | ESSRStGSSSG | PhosphoSitePlus | |
| T848 | RPGLMtKYSTS | PhosphoSitePlus | |
| Dephosphorylation site |
| POLK_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000241436 | R48I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000241436 | F286S | COSMIC | Renal Cancer | 20054297 | ENSP00000241436 | R48I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000241436 | M364L | COSMIC | Renal Cancer | 20054297 |
| Differential expressed protein |
| POLK_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| POLK_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TESK2_HUMAN | POLK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | POLK_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| POLK_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006281 | DNA repair | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006281 | DNA repair | IEA | biological_process |
| GO:0003684 | damaged DNA binding | IEA | molecular_function |
| GO:0006297 | nucleotide-excision repair, DNA gap filling | IMP | biological_process |
| GO:0003887 | DNA-directed DNA polymerase activity | IEA | molecular_function |