| UniProt/SwissProt ID: | LAS1L_HUMAN |
| Description: | LAS1-like (S. cerevisiae) [Source:HGNC Symbol;Acc:25726] |
| Location: | chrX q12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S235 | QDDGKsTESDV | PhosphoSitePlus | |
| S523 | EGSEAsPIGKS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S538 | DSLYWsVKPAS | PhosphoSitePlus | |
| S528 | SPIGKsPYTLD | PhosphoSitePlus | |
| S412 | PALGIsGIRPT | HPRD | |
| Y536 | TLDSLyWSVKP | PhosphoSitePlus | |
| S441 | NARRFsAGQWE | PhosphoSitePlus | |
| S261 | CKKALsHKELY | PhosphoSitePlus | |
| T91 | LAVAStADLIR | Las1 | PhosphoSitePlus |
| S404 | LERMLsELPAL | HPRD | |
| S617 | STGQEsPTAEN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| T619 | GQESPtAENAR | PhosphoSitePlus; HPRD | |
| S363 | GTDPKsHKNVD | PhosphoSitePlus | |
| T91 | LAVAStADLIR | HPRD | |
| S127 | FVNLIsERKTK | HPRD | |
| S534 | PYTLDsLYWSV | PhosphoSitePlus | |
| S127 | FVNLIsERKTK | Las1 | PhosphoSitePlus |
| S90 | PLAVAsTADLI | Las1 | PhosphoSitePlus |
| S560 | QEEQGsVNDVK | PhosphoSitePlus; HPRD | |
| S238 | GKSTEsDVKAD | PhosphoSitePlus | |
| S90 | PLAVAsTADLI | HPRD | |
| Dephosphorylation site |
| LAS1L_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363944 | E556G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363944 | R170C | HPI | Colorectal Cancer | 16959974 | ENSP00000363940 | Q211E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000308649 | Q211E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363944 | Q211E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363944 | C256G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363937 | Q169E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000363944 | R170C | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| LAS1L_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LAS1L_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ST17A_HUMAN | LAS1L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BUB1_HUMAN | LAS1L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| LAS1L_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
| GO:0006364 | rRNA processing | IEA | biological_process |