| UniProt/SwissProt ID: | CDC20_HUMAN |
| Description: | cell division cycle 20 [Source:HGNC Symbol;Acc:1723] |
| Location: | chr1 p34.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T466 | AAADEtLRLWR | WD40 | PhosphoSitePlus |
| T164 | GSSRKtCRYIP | PhosphoSitePlus | |
| S41 | AGPAPsPMRAA | PhosphoSitePlus; phosphoELM; SysPTM | |
| S153 | LKVLYsQKATP | PhosphoSitePlus | |
| S161 | ATPGSsRKTCR | PhosphoSitePlus | |
| S92 | QMEVAsFLLSK | BUB1 | HPRD; RegPhos |
| T106 | PENSQtPTKKE | PhosphoSitePlus; phosphoELM; RegPhos | |
| S170 | CRYIPsLPDRI | PhosphoSitePlus | |
| S51 | ANRSHsAGRTP | PhosphoSitePlus | |
| T69 | SSKVQtTPSKP | PhosphoSitePlus | |
| S92 | QMEVAsFLLSK | PhosphoSitePlus | |
| T59 | RTPGRtPGKSS | PhosphoSitePlus | |
| S161 | ATPGSsRKTCR | BUB1 | HPRD; RegPhos |
| S153 | LKVLYsQKATP | BUB1 | HPRD; RegPhos |
| S49 | RAANRsHSAGR | PhosphoSitePlus | |
| T157 | YSQKAtPGSSR | BUB1 | HPRD; RegPhos |
| S72 | VQTTPsKPGGD | BUB1 | HPRD; RegPhos |
| S72 | VQTTPsKPGGD | PhosphoSitePlus; phosphoELM | |
| T457 | SPDGAtVASAA | WD40 | PhosphoSitePlus |
| T55 | HSAGRtPGRTP | PhosphoSitePlus | |
| T70 | SKVQTtPSKPG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y152 | RLKVLySQKAT | PhosphoSitePlus | |
| S448 | TSRVLsLTMSP | WD40 | PhosphoSitePlus |
| T157 | YSQKAtPGSSR | PhosphoSitePlus | |
| Y79 | PGGDRyIPHRS | PhosphoSitePlus; HPRD | |
| S63 | RTPGKsSSKVQ | HPRD | |
| S64 | TPGKSsSKVQT | HPRD | |
| S41 | AGPAPsPMRAA | BUB1 | HPRD; RegPhos; SysPTM |
| Dephosphorylation site |
| CDC20_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361540 | A434D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000308450 | A434D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000308450 | A434D | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361540 | A434D | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| CDC20_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDC20_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BUB1_HUMAN | CDC20_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | CDC20_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05203 | Viral carcinogenesis |
| hsa04120 | Ubiquitin mediated proteolysis |
| hsa05166 | HTLV-I infection |
| hsa04110 | Cell cycle |
| hsa04114 | Oocyte meiosis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0040020 | regulation of meiosis | IEA | biological_process |
| GO:0050773 | regulation of dendrite development | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0090129 | positive regulation of synapse maturation | ISS | biological_process |
| GO:0051437 | positive regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0090129 | positive regulation of synapse maturation | IEA | biological_process |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0005680 | anaphase-promoting complex | IDA | cellular_component |
| GO:0005813 | centrosome | IEA | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0051439 | regulation of ubiquitin-protein ligase activity in | TAS | biological_process |
| GO:0031915 | positive regulation of synaptic plasticity | ISS | biological_process |
| GO:0007094 | mitotic cell cycle spindle assembly checkpoint | TAS | biological_process |
| GO:0005819 | spindle | TAS | cellular_component |
| GO:0000922 | spindle pole | IEA | cellular_component |
| GO:0051436 | negative regulation of ubiquitin-protein ligase ac | TAS | biological_process |
| GO:0051488 | activation of anaphase-promoting complex activity | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0031915 | positive regulation of synaptic plasticity | IEA | biological_process |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0007049 | cell cycle | TAS | biological_process |
| GO:0008284 | positive regulation of cell proliferation | IEA | biological_process |
| GO:0031145 | anaphase-promoting complex-dependent proteasomal u | IDA | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0051301 | cell division | IEA | biological_process |