Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMCA4_HUMAN
Description:SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [Source:HGNC Symbol;Acc:11100]
Location:chr19 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S655EVAPRsDSEESHPRD
S613ETSQMsDLPVKHPRD; phosphoELM
T1423DAGSStPTTSTPhosphoSitePlus; HPRD
S1642EDRSGsGSEEDPhosphoSitePlus
S660SDSEEsGSEEEHPRD
T353KQSRItPIQKPPhosphoSitePlus
S446RSKRQsLREARPhosphoSitePlus
S1586GEEEGsESESRPhosphoSitePlus; HPRD; phosphoELM
T609EPLDEtSQMSDPhosphoSitePlus; HPRD; phosphoELM
T1396AIEEGtLEEIEPhosphoSitePlus
S1575SEGEEsEEEEEPhosphoSitePlus; HPRD; phosphoELM
S1421DSDAGsSTPTTPhosphoSitePlus
T11PPLGGtPRPGPPhosphoSitePlus; HPRD
S1640QEEDRsGSGSEPhosphoSitePlus; HPRD; phosphoELM
S1642EDRSGsGSEHPRD; phosphoELM
S721DEYGVsQALARPhosphoSitePlus; HPRD; phosphoELM
S662SEESGsEEEEEHPRD
T596NAEGQtPAIGPPhosphoSitePlus
T1384YSDSLtEKQWLHPRD
T1428TPTTStRSRDKPhosphoSitePlus
Y732GLQSYyAVAHAPhosphoSitePlus
T1426SSTPTtSTRSRPhosphoSitePlus
S1422SDAGSsTPTTSPhosphoSitePlus
S323VPPAAsPVMPPPhosphoSitePlus
S1592ESESRsVKVKIPhosphoSitePlus
S1644RSGSGsEHPRD; phosphoELM
S657APRSDsEESGSHPRD
Y1220LAAAKyKLNVDPhosphoSitePlus
S610PLDETsQMSDLBRKPhosphoSitePlus
Y1379RKEVDySDSLTPhosphoSitePlus
S1631VSDDDsEEEQEPhosphoSitePlus; HPRD; phosphoELM
S1417KRKRDsDAGSSPhosphoSitePlus
S613ETSQMsDLPVKBRKPhosphoSitePlus
S624VIHVEsGKILTBRKPhosphoSitePlus
S1644RSGSGsEED__PhosphoSitePlus
S610PLDETsQMSDLHPRD; phosphoELM
T1425GSSTPtTSTRSPhosphoSitePlus
S1371MFGRGsRHRKEPhosphoSitePlus
Y538EDEEGyRKLIDPhosphoSitePlus
S695IPDPDsDDVSEPhosphoSitePlus; HPRD; phosphoELM
T298AAPTStPQKLIPhosphoSitePlus
S1380KEVDYsDSLTEPhosphoSitePlus
Y1123YRGFKyLRLDGHelicase_CPhosphoSitePlus
Y718DVDDEyGVSQAPhosphoSitePlus
S1570EKEDDsEGEESPhosphoSitePlus; HPRD; phosphoELM
T1358EVERLtCEEEEPhosphoSitePlus
S1410RQKKSsRKRKRPhosphoSitePlus
S699DSDDVsEVDARPhosphoSitePlus; HPRD
S1382VDYSDsLTEKQPhosphoSitePlus; HPRD; phosphoELM
S1627AKPVVsDDDSEPhosphoSitePlus; HPRD; phosphoELM
S1452PAEKLsPNPPNPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
SMCA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000395654K586*COSMICLung Cancer21140460
ENSP00000343896F1102LCOSMICOvarian Cancer20826764
ENSP00000395654Q164*COSMICAdrenal Gland Neoplasms
ENSP00000395654R966WTCGAOvarian Cancer21720365, 18772890
ENSP00000395654T910MCOSMICCentral Nervous System Neoplasms21163964
ENSP00000395654R1336HCOSMICIntestines Cancer11085541
ENSP00000343896R1336HCOSMICIntestines Cancer11085541
ENSP00000395654R966WCOSMICOvarian Cancer21720365
ENSP00000343896Q160RCOSMICPancreatic Cancer11085541
ENSP00000343896L1161fs*3COSMICLung Cancer
ENSP00000395654T814KTCGAOvarian Cancer21720365, 18772890
ENSP00000395654G1160RCOSMICLung Cancer15287030
ENSP00000395654L1161fs*3COSMICLung Cancer
ENSP00000343896T58fs*36COSMICLung Cancer18386774
ENSP00000343896A1186VCOSMICIntestines Cancer11085541
ENSP00000395654R1189QCOSMICHead and Neck Cancer21798893
ENSP00000343896M1233ICOSMICMelanoma
ENSP00000395654S767FCOSMICMelanoma21499247
ENSP00000343896S767FCOSMICMelanoma21499247
ENSP00000395654R1601WCOSMICRenal Cancer20054297
ENSP00000343896E1496*COSMICGastric Cancer
ENSP00000343896R1621*COSMICNeoplasms by Histologic Type
ENSP00000343896G44RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000395654M272fs*31COSMICLung Cancer18386774
ENSP00000343896F1234LCOSMICHead and Neck Cancer21798893
ENSP00000395654G44RCOSMICCentral Nervous System Neoplasms18772396
ENSP00000395654T58fs*36COSMICLung Cancer18386774
ENSP00000343896W764RCOSMICLung Cancer
ENSP00000395654L1163PCOSMICIntestines Cancer11085541
ENSP00000395654R885CCOSMICIntestines Cancer11085541
ENSP00000395654G1232DCOSMICCentral Nervous System Neoplasms21163964
ENSP00000343896R1157WCOSMICPancreatic Cancer
ENSP00000395654T814KCOSMICOvarian Cancer21720365
ENSP00000395654K687ECOSMICOvarian Cancer21720365
ENSP00000343896G1160RCOSMICLung Cancer15287030
ENSP00000343896K687ECOSMICOvarian Cancer21720365
ENSP00000395654E1496*COSMICGastric Cancer
ENSP00000395654E1399*COSMICLung Cancer
ENSP00000343896D1284NCOSMICIntestines Cancer11085541
ENSP00000395654W764RCOSMICLung Cancer
ENSP00000343896E403GCOSMICOvarian Cancer11085541
ENSP00000395654M1233ICOSMICMelanoma
ENSP00000343896E1399*COSMICLung Cancer
ENSP00000343896Q544*COSMICBreast Cancer11085541
ENSP00000343896L1609PCOSMICCentral Nervous System Neoplasms11085541
ENSP00000343896E1582*COSMICHepatocellular Carcinoma
ENSP00000343896Q1196*COSMICPancreatic Cancer
ENSP00000343896R885CCOSMICIntestines Cancer11085541
ENSP00000395654D1284NCOSMICIntestines Cancer11085541
ENSP00000343896R1135WBIOMARTBrain Cancer21930507, 21930502
ENSP00000343896R966WCOSMICOvarian Cancer21720365
ENSP00000395654F1102LCOSMICOvarian Cancer20826764
ENSP00000343896R966WTCGAOvarian Cancer21720365, 18772890
ENSP00000395654P244fs*59COSMICPancreatic Cancer11085541
ENSP00000395654Q160RCOSMICPancreatic Cancer11085541
ENSP00000343896E1056*COSMICLung Cancer18386774
ENSP00000343896G1232DCOSMICCentral Nervous System Neoplasms21163964
ENSP00000343896K687ETCGAOvarian Cancer21720365, 18772890
ENSP00000343896Q164*COSMICAdrenal Gland Neoplasms
ENSP00000395654E1310*COSMICLung Cancer
ENSP00000343896G1232SBIOMARTBrain Cancer21930507, 21930502
ENSP00000395654Q1196*COSMICPancreatic Cancer
ENSP00000395654F1234LCOSMICHead and Neck Cancer21798893
ENSP00000395654E1056*COSMICLung Cancer18386774
ENSP00000343896M272fs*31COSMICLung Cancer18386774
ENSP00000343896E1310*COSMICLung Cancer
ENSP00000395654E1582*COSMICHepatocellular Carcinoma
ENSP00000343896P197SCOSMICBreast Cancer11085541
ENSP00000395654E403GCOSMICOvarian Cancer11085541
ENSP00000343896S1176CCOSMICLung Cancer15287030
ENSP00000343896R1189QCOSMICHead and Neck Cancer21798893
ENSP00000395654R1157WCOSMICPancreatic Cancer
ENSP00000343896E821KBIOMARTBrain Cancer21930507, 21930502
ENSP00000395654Q544*COSMICBreast Cancer11085541
ENSP00000343896R1491*COSMICHepatocellular Carcinoma21822264
ENSP00000343896L1163PCOSMICIntestines Cancer11085541
ENSP00000343896T814KCOSMICOvarian Cancer21720365
ENSP00000343896P244fs*59COSMICPancreatic Cancer11085541
ENSP00000395654R1621*COSMICNeoplasms by Histologic Type
ENSP00000343896T910MCOSMICCentral Nervous System Neoplasms21163964
ENSP00000395654L1609PCOSMICCentral Nervous System Neoplasms11085541
ENSP00000395654K687ETCGAOvarian Cancer21720365, 18772890
ENSP00000343896R1601WCOSMICRenal Cancer20054297
ENSP00000395654S1176CCOSMICLung Cancer15287030
ENSP00000395654P197SCOSMICBreast Cancer11085541
ENSP00000395654A1186VCOSMICIntestines Cancer11085541
ENSP00000395654R1077*COSMICPancreatic Cancer
ENSP00000343896R1077*COSMICPancreatic Cancer
ENSP00000343896T814KTCGAOvarian Cancer21720365, 18772890
ENSP00000395654R1491*COSMICHepatocellular Carcinoma21822264
ENSP00000343896K586*COSMICLung Cancer21140460

Differential expressed protein
SMCA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMCA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BUB1_HUMANSMCA4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SMCA4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006338chromatin remodelingIDAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0048730epidermis morphogenesisIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0050681androgen receptor bindingIPImolecular_function
GO:0006346methylation-dependent chromatin silencingIEAbiological_process
GO:0000792heterochromatinIEAcellular_component
GO:0030957Tat protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0016514SWI/SNF complexIDAcellular_component
GO:0000790nuclear chromatinIDAcellular_component
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005719nuclear euchromatinIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0060766negative regulation of androgen receptor signalingIMPbiological_process
GO:0003407neural retina developmentIEPbiological_process
GO:0071565nBAF complexIEAcellular_component
GO:0045749negative regulation of S phase of mitotic cell cycTASbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0001835blastocyst hatchingIEAbiological_process
GO:0008094DNA-dependent ATPase activityIGImolecular_function
GO:0006357regulation of transcription from RNA polymerase IINASbiological_process
GO:0035887aortic smooth muscle cell differentiationIEAbiological_process
GO:0030902hindbrain developmentIEAbiological_process
GO:0060318definitive erythrocyte differentiationIEAbiological_process
GO:0071778WINAC complexIDAcellular_component
GO:0003714transcription corepressor activityIDAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0016818hydrolase activity, acting on acid anhydrides, in IEAmolecular_function
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0016817hydrolase activity, acting on acid anhydridesIEAmolecular_function
GO:0006338chromatin remodelingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0001105RNA polymerase II transcription coactivator activiIDAmolecular_function
GO:0001570vasculogenesisIEAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0019827stem cell maintenanceIEAbiological_process
GO:0001832blastocyst growthIEAbiological_process
GO:0043966histone H3 acetylationIEAbiological_process
GO:0030216keratinocyte differentiationIEAbiological_process
GO:0071564npBAF complexIEAcellular_component
GO:0005726perichromatin fibrilsIEAcellular_component
GO:0007403glial cell fate determinationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0006337nucleosome disassemblyIDAbiological_process
GO:0002039p53 bindingIPImolecular_function
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0003713transcription coactivator activityIMPmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0000902cell morphogenesisIEAbiological_process
GO:0071565nBAF complexISScellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0004386helicase activityIEAmolecular_function
GO:0070577histone acetyl-lysine bindingIDAmolecular_function
GO:0043923positive regulation by host of viral transcriptionIMPbiological_process
GO:0010424DNA methylation on cytosine within a CG sequenceIEAbiological_process
GO:0030308negative regulation of cell growthIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0048562embryonic organ morphogenesisIEAbiological_process
GO:0071564npBAF complexISScellular_component
GO:0060347heart trabecula formationIEAbiological_process
GO:0043388positive regulation of DNA bindingIEAbiological_process