| UniProt/SwissProt ID: | G3BP1_HUMAN |
| Description: | GTPase activating protein (SH3 domain) binding protein 1 [Source:HGNC Symbol;Acc:30292] |
| Location: | chr5 q33.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S250 | DLRTFsWASVT | PhosphoSitePlus | |
| S230 | EDAQKsSSPAP | PhosphoSitePlus; HPRD; phosphoELM | |
| S373 | ELRINsGGKLP | HPRD; phosphoELM | |
| S232 | AQKSSsPAPAD | PhosphoSitePlus; HPRD; phosphoELM | |
| S7 | VMEKPsPLLVG | PhosphoSitePlus | |
| Y363 | DFFQSyGNVVE | RRM_1 | PhosphoSitePlus |
| Y56 | PADAVyGQKEI | HPRD | |
| Y133 | NDIFRyQDEVF | NTF2 | PhosphoSitePlus |
| Y125 | VANKFyVHNDI | NTF2 | PhosphoSitePlus |
| T143 | FGGFVtEPQEE | PhosphoSitePlus; HPRD; phosphoELM | |
| Y56 | PADAVyGQKEI | NTF2 | PhosphoSitePlus |
| T241 | ADIAQtVQEDL | PhosphoSitePlus; HPRD | |
| T222 | PVLEEtAPEDA | PhosphoSitePlus | |
| S388 | VVFDDsEPVQK | RRM_1 | PhosphoSitePlus |
| S231 | DAQKSsSPAPA | PhosphoSitePlus; HPRD; phosphoELM | |
| S373 | ELRINsGGKLP | RRM_1 | PhosphoSitePlus |
| S253 | TFSWAsVTSKN | PhosphoSitePlus | |
| Y174 | DSGTFyDQAVV | HPRD | |
| S47 | HGGLDsNGKPA | NTF2 | PhosphoSitePlus |
| Y133 | NDIFRyQDEVF | HPRD | |
| S149 | EPQEEsEEEVE | PhosphoSitePlus; HPRD; phosphoELM | |
| T162 | EERQQtPEVVP | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| G3BP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000377681 | P316R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000377681 | P316R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000348578 | P316R | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000377681 | P224S | COSMIC | Melanoma | 21499247 | ENSP00000377681 | R423* | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000348578 | Lung Cancer | Treatment (none vs. FK228 treatment) | cell line | Down | 18549279 | ENSP00000348578 | Breast Cancer | Treatment (none vs. 17b-Estradiol treatment) | cell line | Up | 2.9 | 18491314 | ENSP00000348578 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.5 | 20543960 | ENSP00000348578 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20543960 | ENSP00000348578 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.12 | 17655343 | ENSP00000348578 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.15 | 17655343 | ENSP00000348578 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.07 | 17655343 | ENSP00000348578 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Down | 0.23 | 17655343 | ENSP00000348578 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| G3BP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| YES_HUMAN | G3BP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| G3BP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004519 | endonuclease activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0010494 | cytoplasmic stress granule | IEA | cellular_component |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | molecular_function |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0090090 | negative regulation of canonical Wnt receptor sign | IEA | biological_process |
| GO:0006810 | transport | IEA | biological_process |
| GO:0004004 | ATP-dependent RNA helicase activity | TAS | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003729 | mRNA binding | IEA | molecular_function |