Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HSP7C_HUMAN
Description:heat shock 70kDa protein 8 [Source:HGNC Symbol;Acc:5241]
Location:chr11 q24.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T411AGGVMtVLIKRHSP70PhosphoSitePlus
S153AYFNDsQRQATHPRD; phosphoELM
T140LGKTVtNAVVTHSP70PhosphoSitePlus
Y134EIAEAyLGKTVHSP70PhosphoSitePlus
T641ASSGPtIEEHPRD
Y107KVQVEyKGETKHSP70PhosphoSitePlus
S400DVTPLsLGIETHSP70PhosphoSitePlus
T138AYLGKtVTNAVHSP70PhosphoSitePlus
S638SGGASsGPTIEHPRD
S254HKKDIsENKRAHSP70PhosphoSitePlus
T502KENKItITNDKHSP70PhosphoSitePlus
T125SSMVLtKMKEIHSP70PhosphoSitePlus
T163TKDAGtIAGLNHSP70PhosphoSitePlus
Y107KVQVEyKGETKphosphoELM
S277RTLSSsTQASIHSP70PhosphoSitePlus
Y431QTFTTySDNQPHSP70PhosphoSitePlus
S541VSSKNsLESYAHPRD
T66MNPTNtVFDAKHSP70PhosphoSitePlus
T477PQIEVtFDIDAHPRD; phosphoELM
S40NRTTPsYVAFTHSP70PhosphoSitePlus
T177IINEPtAAAIAHSP70PhosphoSitePlus
S221IFEVKsTAGDTHSP70PhosphoSitePlus
Y149VTVPAyFNDSQHSP70PhosphoSitePlus
S329AKLDKsQIHDIHPRD
T298FYTSItRARFEHSP70PhosphoSitePlus
T265VRRLRtACERAHSP70PhosphoSitePlus
S16LGTTYsCVGVFHSP70PhosphoSitePlus
S362KELNKsINPDEHPRD
S254HKKDIsENKRAHPRD
T477PQIEVtFDIDAHSP70PhosphoSitePlus
T341LVGGStRIPKIHSP70PhosphoSitePlus
T462GKFELtGIPPAHPRD
T313DLFRGtLDPVEHSP70PhosphoSitePlus
Y15DLGTTySCVGVHSP70PhosphoSitePlus
T13GIDLGtTYSCVHSP70PhosphoSitePlus
Y41RTTPSyVAFTDHSP70PhosphoSitePlus
Y611IITKLyQSAGGHPRD
T273ERAKRtLSSSTHSP70PhosphoSitePlus
S637PSGGAsSGPTIHPRD
S613TKLYQsAGGMPPhosphoSitePlus
S385LSGDKsENVQDHPRD
T38QGNRTtPSYVAHSP70PhosphoSitePlus
S541VSSKNsLESYAHSP70PhosphoSitePlus
Y525QEAEKyKAEDEHSP70PhosphoSitePlus
Y41RTTPSyVAFTDphosphoELM
T226STAGDtHLGGEHSP70PhosphoSitePlus
S329AKLDKsQIHDIHSP70PhosphoSitePlus
S153AYFNDsQRQATHSP70PhosphoSitePlus
S633GGAPPsGGASSHPRD
S511DKGRLsKEDIEHSP70PhosphoSitePlus
T158SQRQAtKDAGTHSP70PhosphoSitePlus
S544KNSLEsYAFNMHSP70PhosphoSitePlus
T111EYKGEtKSFYPHSP70PhosphoSitePlus
T397LLLDVtPLSLGHPRD
S362KELNKsINPDEHSP70PhosphoSitePlus

Dephosphorylation site
HSP7C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000227378D206GCOSMICCentral Nervous System Neoplasms18772890
ENSP00000227378I403VCOSMICHead and Neck Cancer21798893
ENSP00000437125R262CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000437125D206GCOSMICCentral Nervous System Neoplasms18772890
ENSP00000432083D206GCOSMICCentral Nervous System Neoplasms18772890
ENSP00000432083R262CCOSMICCentral Nervous System Neoplasms18772890
ENSP00000437125I403VCOSMICHead and Neck Cancer21798893
ENSP00000432083I403VCOSMICHead and Neck Cancer21798893
ENSP00000227378R262CCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000227378Non-small cell lung carcinomaMetastasiscell lineUp17537172
ENSP00000227378LeukemiaNormal vs. Cancercell lineUp9.517022645
ENSP00000227378LeukemiaNormal vs. Cancercell lineUp7.217022645
ENSP00000227378Breast CancerNormal vs. Cancercell lineUp314997480
ENSP00000227378Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.918491314
ENSP00000227378Hepatocellular CarcinomaNormal vs. CancertissueUp2.411866469
ENSP00000227378hepatitis B virusNormal vs. CancertissueUp3.514654528
ENSP00000227378hepatitis C virusNormal vs. CancertissueUp3.514654528
ENSP00000227378Hepatocellular CarcinomaNormal vs. CancertissueUp3.514654528
ENSP00000227378Hepatocellular CarcinomaNormal vs. CancertissueDown0.6419956837
ENSP00000227378Lung CancerTreatment(none vs transfected with HPV-16 E7 gene)cell lineUp15684709
ENSP00000227378Lung CancerCancer vs. Cancercell lineUp17284061
ENSP00000227378Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.520804217
ENSP00000227378Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown16525997
ENSP00000227378Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown0.4218253933
ENSP00000227378Gastric CancerNormal vs. CancertissueDown0.2319330469
ENSP00000227378Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000227378breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000227378Oral CancerNormal vs. CancertissueUp5.319691830
ENSP00000227378LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineUp17449014
ENSP00000227378Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineUp5.215169874
ENSP00000227378Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3815169874
ENSP00000227378Renal CancerNormal vs. CancertissueUp19164279
ENSP00000227378MelanomaTreatment (none vs. kojic acid treatment)cell lineDown0.518630942
ENSP00000227378Ovarian CancerMetastasiscell lineDown17892554
ENSP00000227378Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.7119714814
ENSP00000227378Esophageal CancerNormal vs. CancertissueDown0.416400690
ENSP00000227378Gastric CancerNormal vs. CancertissueDown0.215761955
ENSP00000227378Uterine CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000227378Uterine CancerTreatment(21% oxygen vs. 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000227378Head and Neck CancerTreatment(21% oxygen vs. 1% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000227378Head and Neck CancerTreatment(21% oxygen vs 0% oxygen (mild hypoxia) supplemented )cell lineUp19541378
ENSP00000227378Hepatocellular CarcinomaNormal vs. CancertissueUp211866469

Hyperphosphorylation site
HSP7C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
YES_HUMANHSP7C_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
HSP7C_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIDAcellular_component
GO:0005681spliceosomal complexIEAcellular_component
GO:0006457protein foldingNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051726regulation of cell cycleIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0051082unfolded protein bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0016071mRNA metabolic processTASbiological_process
GO:0000974Prp19 complexIDAcellular_component
GO:0042470melanosomeIEAcellular_component
GO:0061202clathrin-sculpted gamma-aminobutyric acid transporTAScellular_component
GO:0016044cellular membrane organizationTASbiological_process
GO:0005829cytosolIEAcellular_component
GO:0006397mRNA processingIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0006457protein foldingIEAbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0005622intracellularNAScellular_component
GO:0005622intracellularIEAcellular_component
GO:0051085chaperone mediated protein folding requiring cofacIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0042623ATPase activity, coupledIEAmolecular_function
GO:0007268synaptic transmissionTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0008380RNA splicingIEAbiological_process
GO:0007269neurotransmitter secretionTASbiological_process
GO:0006892post-Golgi vesicle-mediated transportTASbiological_process
GO:0070062extracellular vesicular exosomeIEAcellular_component
GO:0006986response to unfolded proteinNASbiological_process
GO:0016070RNA metabolic processTASbiological_process