Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CLIC1_HUMAN
Description:chloride intracellular channel 1 [Source:HGNC Symbol;Acc:2062]
Location:chrHSCHR6_MHC_COX p2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S146DNYLTsPLPEEGST_CPhosphoSitePlus
S163EDEGVsQRKFLGST_CPhosphoSitePlus
S163EDEGVsQRKFLHPRD
S103ALNPEsNTAGLPhosphoSitePlus
S211VHRYLsNAYARGST_CPhosphoSitePlus
Y233EIELAyEQVAKPhosphoSitePlus

Dephosphorylation site
CLIC1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364934*242SCOSMICBreast Cancer16959974
ENSP00000379229*242SCOSMICBreast Cancer16959974
ENSP00000364935*242SCOSMICBreast Cancer16959974
ENSP00000364940*242SCOSMICBreast Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000379229Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.318646787
ENSP00000379229Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.418646787
ENSP00000379229Pancreatic CancerNormal vs. CancertissueUp5.616215274
ENSP00000379229Gastric CancerMetastasiscell lineDown2.417022644
ENSP00000379229Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000379229Breast CancerNormal vs. CancertissueUp18257521
ENSP00000379229Breast CancerMetastasistissueDown18257521
ENSP00000379229hepatitis B virusNormal vs. CancertissueUp9.614654528
ENSP00000379229Hepatocellular CarcinomaNormal vs. CancertissueDown0.3814654528
ENSP00000379229hepatitis C virusNormal vs. CancertissueUp1.716097030
ENSP00000379229Hepatocellular CarcinomaMetastasiscell lineUp17214954
ENSP00000379229hepatitis B virusNormal vs. CancertissueUp2.217671684
ENSP00000379229Hepatocellular CarcinomaMetastasiscell lineUp1.619016532
ENSP00000379229Gastric CancerNormal vs. CancertissueDown14711373
ENSP00000379229Gastric CancerMetastasiscell lineDown2.417022644
ENSP00000379229Gastric CancerTreatment (none vs. Vincristine-resistant)cell lineDown0.4318253933
ENSP00000379229Breast CancerNormal vs. CancertissueUp2.520005186
ENSP00000379229Breast CancerNormal vs. Cancercell lineDown0.8820052998
ENSP00000379229Breast CancerNormal vs. Cancercell lineUp1.420052998
ENSP00000379229Breast CancerNormal vs. Cancercell lineUp1.620052998
ENSP00000379229Breast CancerMetastasiscell lineUp1.620052998
ENSP00000379229Breast CancerMetastasiscell lineUp1.820052998
ENSP00000379229Breast CancerNormal vs. CancertissueUp1.820087651
ENSP00000379229Breast CancerMetastasiscell lineUp20155427
ENSP00000379229Oral CancerNormal vs. CancertissueDown0.4519691830
ENSP00000379229chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineDown20417730
ENSP00000379229acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp7.517655343
ENSP00000379229Renal CancerNormal vs. CancertissueUp2.419610612
ENSP00000379229Biliary Tract CancerMetastasiscell lineUp4.719299076
ENSP00000379229Pancreatic CancerNormal vs. CancertissueUp1419199705

Hyperphosphorylation site
CLIC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SCYL2_HUMANCLIC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CLIC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016020membraneIEAcellular_component
GO:0051881regulation of mitochondrial membrane potentialIEAbiological_process
GO:0005254chloride channel activityIDAmolecular_function
GO:0005635nuclear envelopeIDAcellular_component
GO:0031965nuclear membraneIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005634nucleusTAScellular_component
GO:0034707chloride channel complexIEAcellular_component
GO:0006821chloride transportIDAbiological_process
GO:0005247voltage-gated chloride channel activityIEAmolecular_function
GO:0005903brush borderTAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0005739mitochondrionIEAcellular_component


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