| UniProt/SwissProt ID: | CLIC1_HUMAN |
| Description: | chloride intracellular channel 1 [Source:HGNC Symbol;Acc:2062] |
| Location: | chrHSCHR6_MHC_COX p2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S146 | DNYLTsPLPEE | GST_C | PhosphoSitePlus |
| S163 | EDEGVsQRKFL | GST_C | PhosphoSitePlus |
| S163 | EDEGVsQRKFL | HPRD | |
| S103 | ALNPEsNTAGL | PhosphoSitePlus | |
| S211 | VHRYLsNAYAR | GST_C | PhosphoSitePlus |
| Y233 | EIELAyEQVAK | PhosphoSitePlus | |
| Dephosphorylation site |
| CLIC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364934 | *242S | COSMIC | Breast Cancer | 16959974 | ENSP00000379229 | *242S | COSMIC | Breast Cancer | 16959974 | ENSP00000364935 | *242S | COSMIC | Breast Cancer | 16959974 | ENSP00000364940 | *242S | COSMIC | Breast Cancer | 16959974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000379229 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.3 | 18646787 | ENSP00000379229 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.4 | 18646787 | ENSP00000379229 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 5.6 | 16215274 | ENSP00000379229 | Gastric Cancer | Metastasis | cell line | Down | 2.4 | 17022644 | ENSP00000379229 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 17902640 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000379229 | Breast Cancer | Metastasis | tissue | Down | 18257521 | ENSP00000379229 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 9.6 | 14654528 | ENSP00000379229 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.38 | 14654528 | ENSP00000379229 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 1.7 | 16097030 | ENSP00000379229 | Hepatocellular Carcinoma | Metastasis | cell line | Up | 17214954 | ENSP00000379229 | hepatitis B virus | Normal vs. Cancer | tissue | Up | 2.2 | 17671684 | ENSP00000379229 | Hepatocellular Carcinoma | Metastasis | cell line | Up | 1.6 | 19016532 | ENSP00000379229 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 14711373 | ENSP00000379229 | Gastric Cancer | Metastasis | cell line | Down | 2.4 | 17022644 | ENSP00000379229 | Gastric Cancer | Treatment (none vs. Vincristine-resistant) | cell line | Down | 0.43 | 18253933 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | tissue | Up | 2.5 | 20005186 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | cell line | Down | 0.88 | 20052998 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.4 | 20052998 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.6 | 20052998 | ENSP00000379229 | Breast Cancer | Metastasis | cell line | Up | 1.6 | 20052998 | ENSP00000379229 | Breast Cancer | Metastasis | cell line | Up | 1.8 | 20052998 | ENSP00000379229 | Breast Cancer | Normal vs. Cancer | tissue | Up | 1.8 | 20087651 | ENSP00000379229 | Breast Cancer | Metastasis | cell line | Up | 20155427 | ENSP00000379229 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.45 | 19691830 | ENSP00000379229 | chronic myeloid leukemia | Treatment (Imatinib-sensitive vs. Imatinib-resistant) | cell line | Down | 20417730 | ENSP00000379229 | acute myeloid leukemia | Treatment (none vs. NSC606985 treatment) | cell line | Up | 7.5 | 17655343 | ENSP00000379229 | Renal Cancer | Normal vs. Cancer | tissue | Up | 2.4 | 19610612 | ENSP00000379229 | Biliary Tract Cancer | Metastasis | cell line | Up | 4.7 | 19299076 | ENSP00000379229 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 14 | 19199705 |
| Hyperphosphorylation site |
| CLIC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SCYL2_HUMAN | CLIC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CLIC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0051881 | regulation of mitochondrial membrane potential | IEA | biological_process |
| GO:0005254 | chloride channel activity | IDA | molecular_function |
| GO:0005635 | nuclear envelope | IDA | cellular_component |
| GO:0031965 | nuclear membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0034707 | chloride channel complex | IEA | cellular_component |
| GO:0006821 | chloride transport | IDA | biological_process |
| GO:0005247 | voltage-gated chloride channel activity | IEA | molecular_function |
| GO:0005903 | brush border | TAS | cellular_component |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0045669 | positive regulation of osteoblast differentiation | IEA | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |