| UniProt/SwissProt ID: | HS71L_HUMAN |
| Description: | heat shock 70kDa protein 1-like [Source:HGNC Symbol;Acc:5234] |
| Location: | chrHSCHR6_MHC_DBB p2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S420 | LIKRNsTIPTK | HSP70 | PhosphoSitePlus |
| Y117 | ENKAFyPEEIS | HPRD | |
| Y547 | NALESyAFNMK | HSP70 | PhosphoSitePlus |
| T464 | GRFDLtGIPPA | HSP70 | PhosphoSitePlus |
| S256 | HKKDIsQNKRA | HPRD | |
| S122 | YPEEIsSMVLT | HSP70 | PhosphoSitePlus |
| T224 | FEVKAtAGDTH | HPRD | |
| Y373 | DEAVAyGAAVQ | phosphoELM | |
| T132 | TKLKEtAEAFL | HPRD | |
| S364 | RDLNKsINPDE | HSP70 | PhosphoSitePlus |
| T127 | SSMVLtKLKET | HSP70 | PhosphoSitePlus |
| T504 | KVNKItITNDK | HSP70 | PhosphoSitePlus |
| S42 | NRTTPsYVAFT | HSP70 | PhosphoSitePlus |
| S155 | AYFNDsQRQAT | HSP70 | PhosphoSitePlus |
| T68 | MNPQNtVFDAK | HSP70 | PhosphoSitePlus |
| Y17 | DLGTTySCVGV | HSP70 | PhosphoSitePlus |
| T68 | MNPQNtVFDAK | HPRD | |
| Y117 | ENKAFyPEEIS | HSP70 | PhosphoSitePlus |
| T179 | IINEPtAAAIA | HSP70 | PhosphoSitePlus |
| Y43 | RTTPSyVAFTD | HSP70 | PhosphoSitePlus |
| T132 | TKLKEtAEAFL | HSP70 | PhosphoSitePlus |
| S256 | HKKDIsQNKRA | HSP70 | PhosphoSitePlus |
| T300 | FYTSItRARFE | HSP70 | PhosphoSitePlus |
| S123 | PEEISsMVLTK | HSP70 | PhosphoSitePlus |
| T267 | VRRLRtACERA | HSP70 | PhosphoSitePlus |
| S364 | RDLNKsINPDE | HPRD; phosphoELM | |
| T40 | QGNRTtPSYVA | HSP70 | PhosphoSitePlus |
| Dephosphorylation site |
| HS71L_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000387691 | T224N | COSMIC | Neoplasms by Histologic Type | ENSP00000387691 | A548V | COSMIC | Melanoma | 21499247 | ENSP00000364805 | A548V | COSMIC | Melanoma | 21499247 | ENSP00000364805 | E270D | COSMIC | Renal Cancer | 20054297 | ENSP00000387691 | E270D | COSMIC | Renal Cancer | 20054297 | ENSP00000364805 | T224N | COSMIC | Neoplasms by Histologic Type | ENSP00000364805 | E246Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000387691 | E246Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000387691 | E516Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364805 | E516Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000364805 | Oral Cancer | Normal vs. Cancer | tissue | Down | 0.35 | 19297561 |
| Hyperphosphorylation site |
| HS71L_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SCYL2_HUMAN | HS71L_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HS71L_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | biological_process |
| GO:0006986 | response to unfolded protein | TAS | biological_process |
| GO:0005759 | mitochondrial matrix | IEA | cellular_component |
| GO:0008180 | signalosome | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | mitochondrion | IEA | cellular_component |