Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GDNF_HUMAN
Description:glial cell derived neurotrophic factor [Source:HGNC Symbol;Acc:4232]
Location:chr5 p13.2
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S148RYCSGsCDAAETGF_betaPhosphoSitePlus
S146IFRYCsGSCDATGF_betaPhosphoSitePlus
T155DAAETtYDKILTGF_betaPhosphoSitePlus
Y156AAETTyDKILKTGF_betaPhosphoSitePlus
S164ILKNLsRNRRLTGF_betaPhosphoSitePlus

Dephosphorylation site
GDNF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000371248*203LCOSMICHepatocellular Carcinoma21822264
ENSP00000339703A96PBIOMARTBreast Cancer21930507, 21930502
ENSP00000425928A96PBIOMARTBreast Cancer21930507, 21930502
ENSP00000317145A122PBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
GDNF_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GDNF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GDNF_HUMANRET_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
GDNF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007399nervous system developmentTASbiological_process
GO:0001755neural crest cell migrationIDAbiological_process
GO:0072108positive regulation of mesenchymal to epithelial tIEAbiological_process
GO:0021784postganglionic parasympathetic nervous system deveIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0021784postganglionic parasympathetic nervous system deveISSbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0001656metanephros developmentISSbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0005576extracellular regionIDAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0051584regulation of dopamine uptake involved in synapticIDAbiological_process
GO:0031175neuron projection developmentIDAbiological_process
GO:0072107positive regulation of ureteric bud formationIDAbiological_process
GO:0001941postsynaptic membrane organizationIEAbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0048484enteric nervous system developmentISSbiological_process
GO:0048485sympathetic nervous system developmentISSbiological_process
GO:0008083growth factor activityNASmolecular_function
GO:0001657ureteric bud developmentIEAbiological_process
GO:0032770positive regulation of monooxygenase activityIDAbiological_process
GO:0043524negative regulation of neuron apoptotic processIDAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0003337mesenchymal to epithelial transition involved in mIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048255mRNA stabilizationIDAbiological_process
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:2001240negative regulation of extrinsic apoptotic signaliIDAbiological_process
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0090190positive regulation of branching involved in ureteIDAbiological_process
GO:0001759organ inductionIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0048484enteric nervous system developmentIEAbiological_process
GO:0060688regulation of morphogenesis of a branching structuIEAbiological_process
GO:0060688regulation of morphogenesis of a branching structuISSbiological_process
GO:0008344adult locomotory behaviorTASbiological_process
GO:0030432peristalsisIEAbiological_process
GO:0033603positive regulation of dopamine secretionTASbiological_process
GO:0060676ureteric bud formationIEAbiological_process
GO:0001656metanephros developmentIEAbiological_process
GO:0001658branching involved in ureteric bud morphogenesisISSbiological_process
GO:0030432peristalsisISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process