Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INPP_HUMAN
Description:inositol polyphosphate-1-phosphatase [Source:HGNC Symbol;Acc:6071]
Location:chr2 q32.2
Node attribute:Enzyme(target); Enzyme(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T271TSEKEtIKAALInositol_PPhosphoSitePlus
S243SRRNGsETHTGInositol_PPhosphoSitePlus
S81IFGEEsNEFTNInositol_PPhosphoSitePlus
S317TFKWDsCAAHAInositol_PPhosphoSitePlus
S317TFKWDsCAAHAphosphoELM

Dephosphorylation site
INPP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000376142G187CTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000325423C280FCOSMICLung Cancer
ENSP00000440650C280FCOSMICLung Cancer
ENSP00000376142C280FCOSMICLung Cancer
ENSP00000440650G187CTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000325423G187CTCGA, COSMICOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376142Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.2215169874

Hyperphosphorylation site
INPP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
INP4A_HUMANINPP_HUMANenzyme catalysisKEGG
INPP_HUMANPLCD3_HUMANenzyme catalysisKEGG
IMPA1_HUMANINPP_HUMANenzyme catalysisKEGG
INPP_HUMANPI5PA_HUMANenzyme catalysisKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046872metal ion bindingIEAmolecular_function
GO:0006796phosphate-containing compound metabolic processTASbiological_process
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0004441inositol-1,4-bisphosphate 1-phosphatase activityIEAmolecular_function


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