| UniProt/SwissProt ID: | INPP_HUMAN |
| Description: | inositol polyphosphate-1-phosphatase [Source:HGNC Symbol;Acc:6071] |
| Location: | chr2 q32.2 |
| Node attribute: | Enzyme(target); Enzyme(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T271 | TSEKEtIKAAL | Inositol_P | PhosphoSitePlus |
| S243 | SRRNGsETHTG | Inositol_P | PhosphoSitePlus |
| S81 | IFGEEsNEFTN | Inositol_P | PhosphoSitePlus |
| S317 | TFKWDsCAAHA | Inositol_P | PhosphoSitePlus |
| S317 | TFKWDsCAAHA | phosphoELM | |
| Dephosphorylation site |
| INPP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000376142 | G187C | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000325423 | C280F | COSMIC | Lung Cancer | ENSP00000440650 | C280F | COSMIC | Lung Cancer | ENSP00000376142 | C280F | COSMIC | Lung Cancer | ENSP00000440650 | G187C | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 | ENSP00000325423 | G187C | TCGA, COSMIC | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000376142 | Neoplasms by Histologic Type | Treatment (none vs. SB203580 treatment 3 hour) | cell line | Down | 0.22 | 15169874 |
| Hyperphosphorylation site |
| INPP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| INP4A_HUMAN | INPP_HUMAN | enzyme catalysis | KEGG |
| INPP_HUMAN | PLCD3_HUMAN | enzyme catalysis | KEGG |
| IMPA1_HUMAN | INPP_HUMAN | enzyme catalysis | KEGG |
| INPP_HUMAN | PI5PA_HUMAN | enzyme catalysis | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa01100 | Metabolic pathways |
| hsa00562 | Inositol phosphate metabolism |
| hsa04070 | Phosphatidylinositol signaling system |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006796 | phosphate-containing compound metabolic process | TAS | biological_process |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity | IEA | molecular_function |