| UniProt/SwissProt ID: | IMPA1_HUMAN |
| Description: | inositol(myo)-1(or 4)-monophosphatase 1 [Source:HGNC Symbol;Acc:6050] |
| Location: | chr8 q21.13 |
| Node attribute: | Enzyme(source); Enzyme(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T168 | LGSSRtPETVR | Inositol_P | PhosphoSitePlus |
| S38 | VMLKSsPVDLV | Inositol_P | PhosphoSitePlus |
| S56 | EKMLIsSIKEK | Inositol_P | PhosphoSitePlus |
| S37 | NVMLKsSPVDL | HPRD; phosphoELM | |
| T44 | PVDLVtATDQK | Inositol_P | PhosphoSitePlus |
| T161 | KSLLVtELGSS | Inositol_P | PhosphoSitePlus |
| Dephosphorylation site |
| IMPA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000256108 | G164S | COSMIC | Melanoma | |
| Differential expressed protein |
| IMPA1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IMPA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| IMPA1_HUMAN | IMPA1_HUMAN | enzyme catalysis | KEGG |
| IMPA1_HUMAN | INP4A_HUMAN | enzyme catalysis | KEGG |
| CDIPT_HUMAN | IMPA1_HUMAN | enzyme catalysis | KEGG |
| IMPA1_HUMAN | INPP_HUMAN | enzyme catalysis | KEGG |
| PLCD3_HUMAN | IMPA1_HUMAN | enzyme catalysis | KEGG |
| MTM1_HUMAN | IMPA1_HUMAN | enzyme catalysis | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04070 | Phosphatidylinositol signaling system |
| hsa00562 | Inositol phosphate metabolism |
| hsa01100 | Metabolic pathways |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0046855 | inositol phosphate dephosphorylation | IDA | biological_process |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0006796 | phosphate-containing compound metabolic process | IMP | biological_process |
| GO:0007165 | signal transduction | IMP | biological_process |
| GO:0042803 | protein homodimerization activity | IPI | molecular_function |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0052832 | inositol monophosphate 3-phosphatase activity | IEA | molecular_function |
| GO:0052833 | inositol monophosphate 4-phosphatase activity | IEA | molecular_function |
| GO:0008934 | inositol monophosphate 1-phosphatase activity | IMP | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0006661 | phosphatidylinositol biosynthetic process | IMP | biological_process |
| GO:0006021 | inositol biosynthetic process | IEA | biological_process |