Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MAPK2_HUMAN
Description:mitogen-activated protein kinase-activated protein kinase 2 [Source:HGNC Symbol;Acc:6887]
Location:chrHG1293_PATCH q32.
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T25PPQPPtPALPHp38aRegPhos
T25PPQPPtPALPHMAPK14HPRD; phosphoELM
T334TKVPQtPLHTSMAPK14HPRD; phosphoELM
Y225LTTPCyTPYYVPkinasePhosphoSitePlus
T334TKVPQtPLHTSMAPK_groupphosphoELM; RegPhos
S272HGLAIsPGMKTPkinasePhosphoSitePlus
T206AILKLtDFGFAMAPK14HPRD
T222HNSLTtPCYTPp38a(MAPK14RegPhos
T214GFAKEtTSHNSPkinasePhosphoSitePlus
S9NSQGQsPPVPFMAPK1phosphoELM
S328PWIMQsTKVPQautocatalysis RegPhos
T222HNSLTtPCYTPphosphoELM
S272HGLAIsPGMKTMAPK_groupphosphoELM; RegPhos
S9NSQGQsPPVPFPhosphoSitePlus
T338QTPLHtSRVLKPhosphoSitePlus; HPRD; RegPhos
S339TPLHTsRVLKEPhosphoSitePlus
T221SHNSLtTPCYTPkinasePhosphoSitePlus
T25PPQPPtPALPHMAPK_groupphosphoELM; RegPhos
T206AILKLtDFGFAPkinasePhosphoSitePlus
T66DDYKVtSQVLGPkinasePhosphoSitePlus
T215FAKETtSHNSLPkinasePhosphoSitePlus
T226TTPCYtPYYVAPkinasePhosphoSitePlus
S272HGLAIsPGMKTp38a(MAPK14RegPhos
T222HNSLTtPCYTPp38aRegPhos
S9NSQGQsPPVPFErk2(MAPK1RegPhos
T334TKVPQtPLHTSPhosphoSitePlus; phosphoELM
T317QRMTItEFMNHMAPK14HPRD
S272HGLAIsPGMKTp38aRegPhos
T206AILKLtDFGFAp38aRegPhos
Y367TMRVDyEQIKIPhosphoSitePlus
T222HNSLTtPCYTPPkinasePhosphoSitePlus
T338QTPLHtSRVLKMAPKAPK2phosphoELM; RegPhos
T317QRMTItEFMNHp38aRegPhos
T25PPQPPtPALPHp38a(MAPK14RegPhos
T222HNSLTtPCYTPMAPK14HPRD; phosphoELM
T25PPQPPtPALPHPhosphoSitePlus
S219TTSHNsLTTPCPkinasePhosphoSitePlus
S328PWIMQsTKVPQPhosphoSitePlus
T329WIMQStKVPQTPhosphoSitePlus
S272HGLAIsPGMKTMAPK14HPRD; phosphoELM
T317QRMTItEFMNHPkinasePhosphoSitePlus
Y63AIIDDyKVTSQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S67DYKVTsQVLGLPkinasePhosphoSitePlus
T334TKVPQtPLHTSp38a(MAPK14RegPhos
T222HNSLTtPCYTPMAPK_groupphosphoELM; RegPhos
T334TKVPQtPLHTSp38aRegPhos

Dephosphorylation site
MAPK2_HUMAN do not have dephosphorylation site.

Mutation site
MAPK2_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356070Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3715169874

Hyperphosphorylation site
MAPK2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MAPK2_HUMANHSPB1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANHSF1_HUMANkinase -> substrateRegPhos
MAPK2_HUMAN1433Z_HUMANkinase -> substrateHPRD; RegPhos
MK14_HUMANMAPK2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MAPK2_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos; NetPath
MAPK2_HUMANCPZIP_HUMANkinase -> substrateRegPhos
MAPK2_HUMANSRF_HUMANkinase -> substrateRegPhos
MAPK2_HUMANZN823_HUMANkinase -> substrateRegPhos
MAPK2_HUMANVIME_HUMANkinase -> substrateRegPhos
MK01_HUMANMAPK2_HUMANkinase -> substrateRobert H Newman (2013)
MAPK2_HUMANARPC5_HUMANkinase -> substrateHPRD
MAPK2_HUMANETV1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANBAG2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANMAPK2_HUMANkinase -> substrateRegPhos
MAPK2_HUMANTY3H_HUMANkinase -> substrateRegPhos
MAPK2_HUMANESR1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANEF2K_HUMANkinase -> substrateHPRD; RegPhos
MAPK2_HUMANLSP1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANMPIP2_HUMANkinase -> substrateRegPhos
MAPK2_HUMANNCOA1_HUMANkinase -> substrateRegPhos
MAPK2_HUMANMAPK2_HUMANkinase -> substrateRegPhos
MAPK2_HUMANTSC2_HUMANkinase -> substrateHPRD; RegPhos
MAPK2_HUMANLOX5_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04370VEGF signaling pathway
hsa04010MAPK signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05203Viral carcinogenesis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0044351macropinocytosisISSbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0002224toll-like receptor signaling pathwayISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048839inner ear developmentIEAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0000165MAPK cascadeTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0048010vascular endothelial growth factor receptor signalIMPbiological_process
GO:0048255mRNA stabilizationIEAbiological_process
GO:0007265Ras protein signal transductionTASbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:0010467gene expressionTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0031572G2/M transition DNA damage checkpointIMPbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0032680regulation of tumor necrosis factor productionIDAbiological_process
GO:0032496response to lipopolysaccharideISSbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0032675regulation of interleukin-6 productionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006468protein phosphorylationTASbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006954inflammatory responseIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0032675regulation of interleukin-6 productionISSbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0004871signal transducer activityTASmolecular_function
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0044351macropinocytosisIEAbiological_process
GO:0006950response to stressIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:00709353'-UTR-mediated mRNA stabilizationIDAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0002224toll-like receptor signaling pathwayIEAbiological_process
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0006954inflammatory responseISSbiological_process