| UniProt/SwissProt ID: | ARPC5_HUMAN |
| Description: | actin related protein 2/3 complex, subunit 5, 16kDa [Source:HGNC Symbol;Acc:708] |
| Location: | chr1 q25.3 |
| Node attribute: | substrate; PPI(target) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S140 | AGGVGsIVRVL | P16-Arc | PhosphoSitePlus |
| T146 | IVRVLtARKTV | P16-Arc | PhosphoSitePlus |
| S77 | KDRAGsIVLKV | MAPKAPK2 | HPRD |
| Y19 | VDVDEyDENKF | P16-Arc | PhosphoSitePlus |
| S77 | KDRAGsIVLKV | P16-Arc | PhosphoSitePlus |
| Dephosphorylation site |
| ARPC5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ARPC5_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000352918 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| ARPC5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MAPK2_HUMAN | ARPC5_HUMAN | kinase -> substrate | HPRD |
| WASP_HUMAN | ARPC5_HUMAN | other | KEGG |
| WASF2_HUMAN | ARPC5_HUMAN | other | KEGG |
| SL9A1_HUMAN | ARPC5_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05132 | Salmonella infection |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa05131 | Shigellosis |
| hsa05130 | Pathogenic Escherichia coli infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030036 | actin cytoskeleton organization | TAS | biological_process |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0005885 | Arp2/3 protein complex | TAS | cellular_component |
| GO:0030027 | lamellipodium | IEA | cellular_component |
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0030833 | regulation of actin filament polymerization | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |