UniProt/SwissProt ID: | KC1D_HUMAN |
Description: | casein kinase 1, delta [Source:HGNC Symbol;Acc:2452] |
Location: | chr17 q25.3 |
Node attribute: | kinase |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S350 | PLTPTsHTANT | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
S411 | SSGLQsVVHR_ | PhosphoSitePlus | |
T344 | EVAPPtPLTPT | PhosphoSitePlus; HPRD | |
S398 | SRMSTsQNSIP | HPRD | |
S331 | LPSTAsGRLRG | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
T387 | SSSDLtGRQDT | PhosphoSitePlus; HPRD | |
T397 | TSRMStSQNSI | HPRD | |
S398 | SRMSTsQIPGR | PhosphoSitePlus | |
T329 | RGLPStASGRL | HPRD; phosphoELM | |
S407 | GRVASsGLQSV | PhosphoSitePlus; HPRD | |
T349 | TPLTPtSHTAN | PhosphoSitePlus; HPRD; phosphoELM | |
S356 | HTANTsPRPVS | PhosphoSitePlus; HPRD; phosphoELM | |
S328 | TRGLPsTASGR | PhosphoSitePlus; HPRD; phosphoELM | |
T355 | SHTANtSPRPV | PhosphoSitePlus; HPRD | |
T347 | PPTPLtPTSHT | PhosphoSitePlus; HPRD; phosphoELM | |
T352 | TPTSHtANTSP | HPRD | |
S401 | STSQNsIPFEH | HPRD | |
S406 | PGRVAsSGLQS | PhosphoSitePlus; HPRD; SysPTM | |
S382 | APVNIsSSDLT | PhosphoSitePlus; HPRD; phosphoELM | |
S234 | SEKKMsTPIEV | HPRD | |
S383 | PVNISsSDLTG | PhosphoSitePlus; HPRD; phosphoELM | |
S396 | DTSRMsTSQNS | HPRD | |
S361 | SPRPVsGMERE | PhosphoSitePlus; HPRD; phosphoELM | |
S384 | VNISSsDLTGR | PhosphoSitePlus; HPRD; phosphoELM | |
Dephosphorylation site |
KC1D_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000324464 | S97C | Sjoblom2006, HPI, BIOMART, Greenman2007 | Breast Cancer | 15908952, 16959974, 17344846, 18428421, 21930507, 21930502, 16959974, 17344846, 16959974 17344846 |
ENSP00000324464 | D265G | COSMIC | Ovarian Cancer | 20826764 |
Differential expressed protein |
KC1D_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
KC1D_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
KC1D_HUMAN | IASPP_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | TFAM_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | MK01_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | UHMK1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | E2F1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | DVL3_HUMAN | kinase -> substrate | NetPath |
KC1D_HUMAN | PER1_HUMAN | kinase -> substrate | KEGG |
KC1D_HUMAN | CTNB1_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | NFAC3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | CDK5_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | PER2_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | PSN2_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
KC1D_HUMAN | CXA1_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | BACE1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
KC1D_HUMAN | P53_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | BMX_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KC1D_HUMAN | DVL2_HUMAN | kinase -> substrate | NetPath |
KC1D_HUMAN | SYUA_HUMAN | kinase -> substrate | HPRD |
KC1D_HUMAN | MK08_HUMAN | kinase -> substrate | Robert H Newman (2013) |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04340 | Hedgehog signaling pathway |
hsa04710 | Circadian rhythm - mammal |
hsa04540 | Gap junction |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
GO:0005819 | spindle | IDA | cellular_component |
GO:0005886 | plasma membrane | IDA | cellular_component |
GO:0007165 | signal transduction | TAS | biological_process |
GO:0000278 | mitotic cell cycle | TAS | biological_process |
GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
GO:0005515 | protein binding | IPI | molecular_function |
GO:0006281 | DNA repair | TAS | biological_process |
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
GO:0005829 | cytosol | TAS | cellular_component |
GO:0032436 | positive regulation of proteasomal ubiquitin-depen | ISS | biological_process |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0006468 | protein phosphorylation | IDA | biological_process |
GO:0001934 | positive regulation of protein phosphorylation | IMP | biological_process |
GO:0048471 | perinuclear region of cytoplasm | IDA | cellular_component |
GO:0005634 | nucleus | ISS | cellular_component |
GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
GO:0005634 | nucleus | IEA | cellular_component |
GO:0005794 | Golgi apparatus | IDA | cellular_component |
GO:0005813 | centrosome | IDA | cellular_component |
GO:0051225 | spindle assembly | IDA | biological_process |
GO:0042752 | regulation of circadian rhythm | ISS | biological_process |
GO:0005524 | ATP binding | IEA | molecular_function |
GO:0004672 | protein kinase activity | ISS | molecular_function |
GO:0032922 | circadian regulation of gene expression | ISS | biological_process |
GO:0005876 | spindle microtubule | IDA | cellular_component |
GO:0032922 | circadian regulation of gene expression | IEA | biological_process |
GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
GO:0032436 | positive regulation of proteasomal ubiquitin-depen | IEA | biological_process |
GO:0090263 | positive regulation of canonical Wnt receptor sign | IMP | biological_process |
GO:0042752 | regulation of circadian rhythm | IEA | biological_process |
GO:0050321 | tau-protein kinase activity | IEA | molecular_function |