Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KC1D_HUMAN
Description:casein kinase 1, delta [Source:HGNC Symbol;Acc:2452]
Location:chr17 q25.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S350PLTPTsHTANTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S411SSGLQsVVHR_PhosphoSitePlus
T344EVAPPtPLTPTPhosphoSitePlus; HPRD
S398SRMSTsQNSIPHPRD
S331LPSTAsGRLRGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T387SSSDLtGRQDTPhosphoSitePlus; HPRD
T397TSRMStSQNSIHPRD
S398SRMSTsQIPGRPhosphoSitePlus
T329RGLPStASGRLHPRD; phosphoELM
S407GRVASsGLQSVPhosphoSitePlus; HPRD
T349TPLTPtSHTANPhosphoSitePlus; HPRD; phosphoELM
S356HTANTsPRPVSPhosphoSitePlus; HPRD; phosphoELM
S328TRGLPsTASGRPhosphoSitePlus; HPRD; phosphoELM
T355SHTANtSPRPVPhosphoSitePlus; HPRD
T347PPTPLtPTSHTPhosphoSitePlus; HPRD; phosphoELM
T352TPTSHtANTSPHPRD
S401STSQNsIPFEHHPRD
S406PGRVAsSGLQSPhosphoSitePlus; HPRD; SysPTM
S382APVNIsSSDLTPhosphoSitePlus; HPRD; phosphoELM
S234SEKKMsTPIEVHPRD
S383PVNISsSDLTGPhosphoSitePlus; HPRD; phosphoELM
S396DTSRMsTSQNSHPRD
S361SPRPVsGMEREPhosphoSitePlus; HPRD; phosphoELM
S384VNISSsDLTGRPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
KC1D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324464S97CSjoblom2006, HPI, BIOMART, Greenman2007Breast Cancer15908952, 16959974, 17344846, 18428421, 21930507, 21930502, 16959974, 17344846, 16959974 17344846
ENSP00000324464D265GCOSMICOvarian Cancer20826764

Differential expressed protein
KC1D_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KC1D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1D_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANTFAM_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANMK01_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANE2F1_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANDVL3_HUMANkinase -> substrateNetPath
KC1D_HUMANPER1_HUMANkinase -> substrateKEGG
KC1D_HUMANCTNB1_HUMANkinase -> substrateHPRD
KC1D_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANCDK5_HUMANkinase -> substrateHPRD
KC1D_HUMANPER2_HUMANkinase -> substrateHPRD
KC1D_HUMANPSN2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1D_HUMANCXA1_HUMANkinase -> substrateHPRD
KC1D_HUMANBACE1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1D_HUMANP53_HUMANkinase -> substrateHPRD
KC1D_HUMANBMX_HUMANkinase -> substrateRobert H Newman (2013)
KC1D_HUMANDVL2_HUMANkinase -> substrateNetPath
KC1D_HUMANSYUA_HUMANkinase -> substrateHPRD
KC1D_HUMANMK08_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04340Hedgehog signaling pathway
hsa04710Circadian rhythm - mammal
hsa04540Gap junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0005819spindleIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006281DNA repairTASbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0032436positive regulation of proteasomal ubiquitin-depenISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0005634nucleusISScellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0051225spindle assemblyIDAbiological_process
GO:0042752regulation of circadian rhythmISSbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityISSmolecular_function
GO:0032922circadian regulation of gene expressionISSbiological_process
GO:0005876spindle microtubuleIDAcellular_component
GO:0032922circadian regulation of gene expressionIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0032436positive regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:0042752regulation of circadian rhythmIEAbiological_process
GO:0050321tau-protein kinase activityIEAmolecular_function


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