Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LSR_HUMAN
Description:lipolysis stimulated lipoprotein receptor [Source:HGNC Symbol;Acc:29572]
Location:chr19 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y372GGQGSyVPLLRPhosphoSitePlus; HPRD; SysPTM
T505LTPPStAESGSPhosphoSitePlus
Y623PAPPPySETDSPhosphoSitePlus; HPRD
Y406SMRVLyYMEKEPhosphoSitePlus; HPRD; phosphoELM
T453RGPALtPIRDEPhosphoSitePlus
S510TAESGsRSPTSPhosphoSitePlus
S432VERAMsEVTSLPhosphoSitePlus; HPRD
S631TDSQAsRERRLPhosphoSitePlus
S332TYAHLsPAKTPPhosphoSitePlus; HPRD
T327IYAPStYAHLSPhosphoSitePlus
S382RDTDSsVASEVPhosphoSitePlus
S646ALSREsLVV__PhosphoSitePlus
S365VDRSSsAGGQGPhosphoSitePlus
Y615EEEEAyYPPAPPhosphoSitePlus; HPRD; phosphoELM
S581DNGSRsGDLPYPhosphoSitePlus; HPRD
S624APPPYsETDSQPhosphoSitePlus
S436MSEVTsLHEDDPhosphoSitePlus; HPRD
Y523GRSRAyMPPRSPhosphoSitePlus
Y586SGDLPyDGRLLPhosphoSitePlus; HPRD; phosphoELM
S321TSGVPsIYAPSPhosphoSitePlus
S646ALSREsLHPRD; phosphoELM
Y309CPEALyAAGKAPhosphoSitePlus; HPRD; phosphoELM
S401SQQDDsMRVLYPhosphoSitePlus
S464EWGGHsPRSPRPhosphoSitePlus; HPRD
S530PPRSRsRDDLYPhosphoSitePlus; HPRD
T379PLLRDtDSSVAPhosphoSitePlus
S508PSTAEsGSRSPPhosphoSitePlus
Y407MRVLYyMEKELPhosphoSitePlus; HPRD
S540YDQDDsRDFPRPhosphoSitePlus; HPRD
S643KNLALsRESLHPRD
S546RDFPRsRDPHYPhosphoSitePlus
S528YMPPRsRSRDDPhosphoSitePlus; HPRD
S381LRDTDsSVASEPhosphoSitePlus
S371AGGQGsYVPLLPhosphoSitePlus
S504DLTPPsTAESGPhosphoSitePlus
Y323GVPSIyAPSTYPhosphoSitePlus; HPRD
Y551SRDPHyDDFRSPhosphoSitePlus; HPRD; phosphoELM
S467GHSPRsPRGWDPhosphoSitePlus
Y550RSRDPhYDDFRHPRD
S556YDDFRsRERPPPhosphoSitePlus
Y391EVRSGyRIQASPhosphoSitePlus
S579PRDNGsRSGDLPhosphoSitePlus
S14GTRNGsGKGRSHPRD
S363GDVDRsSSAGGPhosphoSitePlus
T501ALDDLtPPSTAPhosphoSitePlus; HPRD; phosphoELM
T514GSRSPtSNGGRPhosphoSitePlus; HPRD; phosphoELM
Y352PAYNGyPGGYPPhosphoSitePlus
S326SIYAPsTYAHLPhosphoSitePlus; HPRD
S512ESGSRsPTSNGPhosphoSitePlus
Y328YAPSTyAHLSPPhosphoSitePlus; HPRD; phosphoELM
Y349PMGPAyNGYPGPhosphoSitePlus
Y616EEEAYyPPAPPPhosphoSitePlus; HPRD
S493RPRARsVDALDPhosphoSitePlus; HPRD; phosphoELM
Y535SRDDLyDQDDSPhosphoSitePlus; HPRD; phosphoELM
S643KNLALsRESLVPhosphoSitePlus

Dephosphorylation site
LSR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354575S332FBIOMARTBreast Cancer21930507, 21930502
ENSP00000262627S295FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354575Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4619329653

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y323TSGVPSIyAPSTYAHcholangiocellular carcinoma21253578PhosphoSitePlus
Y535SRSRDDLyDQDDSRDcholangiocellular carcinoma21253578PhosphoSitePlus
Y551PRSRDPHyDDFRSREcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
FGFR1_HUMANLSR_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
LSR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016021integral to membraneIEAcellular_component
GO:0042627chylomicronIEAcellular_component
GO:0001889liver developmentISSbiological_process
GO:0019216regulation of lipid metabolic processIEAbiological_process
GO:0009790embryo developmentISSbiological_process
GO:0034361very-low-density lipoprotein particleIEAcellular_component
GO:0001889liver developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0034362low-density lipoprotein particleIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0005886plasma membraneISScellular_component