| UniProt/SwissProt ID: | DDX6_HUMAN |
| Description: | DEAD (Asp-Glu-Ala-Asp) box helicase 6 [Source:HGNC Symbol;Acc:2747] |
| Location: | chr11 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T439 | AINLItYDDRF | PhosphoSitePlus | |
| T327 | VHCLNtLFSRL | PhosphoSitePlus | |
| S475 | VAEYHsEPVED | PhosphoSitePlus; HPRD | |
| T36 | PGGGGtQTQQQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T199 | AKVMAtTGGTN | DEAD | PhosphoSitePlus |
| Y312 | KGVTQyYAYVT | PhosphoSitePlus | |
| Y472 | SLYVAeYHSEP | HPRD | |
| Y440 | INLITyDDRFN | PhosphoSitePlus | |
| T87 | DLRIKtSDVTS | PhosphoSitePlus | |
| Y313 | GVTQYyAYVTE | PhosphoSitePlus | |
| Y473 | LYVAEyHSEPV | PhosphoSitePlus; HPRD | |
| S330 | LNTLFsRLQIN | PhosphoSitePlus | |
| T199 | AKVMAtTGGTN | HPRD | |
| Y469 | IDKSLyVAEYH | PhosphoSitePlus | |
| S16 | IMGLSsQNGQL | PhosphoSitePlus | |
| T38 | GGGTQtQQQMN | PhosphoSitePlus | |
| Dephosphorylation site |
| DDX6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| DDX6_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000264018 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| DDX6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FGFR1_HUMAN | DDX6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| DDX6_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0033962 | cytoplasmic mRNA processing body assembly | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0003724 | RNA helicase activity | TAS | molecular_function |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0000932 | cytoplasmic mRNA processing body | IDA | cellular_component |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0016442 | RNA-induced silencing complex | IDA | cellular_component |
| GO:0008026 | ATP-dependent helicase activity | IEA | molecular_function |
| GO:0010494 | cytoplasmic stress granule | IDA | cellular_component |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0004386 | helicase activity | TAS | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0000288 | nuclear-transcribed mRNA catabolic process, deaden | TAS | biological_process |
| GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |